Hypoxia‐driven immunosuppression by Treg and type‐2 conventional dendritic cells in HCC

Author:

Suthen Sheena1,Lim Chun Jye1,Nguyen Phuong H. D.1,Dutertre Charles‐Antoine23,Lai Hannah L. H.4,Wasser Martin1ORCID,Chua Camillus1,Lim Tony K. H.56,Leow Wei Qiang56,Loh Tracy Jiezhen56,Wan Wei Keat56,Pang Yin Huei7,Soon Gwyneth7,Cheow Peng Chung58,Kam Juinn Huar58,Iyer Shridhar9,Kow Alfred9,Tam Wai Leong4101112,Shuen Timothy W. H.13,Toh Han Chong513,Dan Yock Young14,Bonney Glenn K.9,Chan Chung Yip58,Chung Alexander58,Goh Brian K. P.58,Zhai Weiwei21516,Ginhoux Florent23,Chow Pierce K. H.817,Albani Salvatore1,Chew Valerie1ORCID

Affiliation:

1. Translational Immunology Institute SingHealth Duke–NUS Academic Medical Center Singapore

2. Gustave Roussy Cancer Campus Villejuif France

3. Institut National de la Santé Et de la Recherche Médicale (INSERM) U1015 Equipe Labellisée—Ligue Nationale Contre le Cancer Villejuif France

4. Agency for Science, Technology and Research Genome Institute of Singapore Singapore

5. Duke–NUS Medical School Singapore

6. Department of Anatomical Pathology Singapore General Hospital Singapore

7. Department of Pathology National University Hospital Singapore

8. Division of Surgery and Surgical Oncology Department of Hepatopancreatobiliary and Transplant Surgery Singapore General Hospital and National Cancer Center Singapore Singapore

9. Division of Hepatobiliary and Pancreatic Surgery Department of Surgery University Surgical Cluster National University Health System Singapore

10. School of Biological Sciences Nanyang Technological University Singapore

11. Cancer Science Institute of Singapore National University of Singapore Singapore

12. Department of Biochemistry Yong Loo Lin School of Medicine National University of Singapore Singapore

13. Division of Medical Oncology National Cancer Center Singapore Singapore

14. Department of Medicine Yong Loo Lin School of Medicine National University of Singapore Singapore

15. Key Laboratory of Zoological Systematics and Evolution Institute of Zoology Chinese Academy of Sciences Beijing China

16. Center for Excellence in Animal Evolution and Genetics Chinese Academy of Sciences Kunming China

17. Academic Clinical Programme for Surgery SingHealth Duke‐NUS Academic Medical Centre Singapore

Funder

National Medical Research Council

Publisher

Ovid Technologies (Wolters Kluwer Health)

Subject

Hepatology

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