Fertility preservation in pediatric central nervous system tumors: A report from the Children's Oncology Group-Reference-Cited by-同舟云学术

Fertility preservation in pediatric central nervous system tumors: A report from the Children's Oncology Group

Published:2024-08-10 Issue: Volume: Page:
ISSN:1545-5009
Container-title:Pediatric Blood & Cancer
language:en
Short-container-title:Pediatric Blood & Cancer

Author:

Felker James¹²^ORCID,Bjornard Kari³⁴^ORCID,Close Allison⁵^ORCID,Chavez Josuah⁶,Chow Eric J.⁷,Meacham Lillian R.⁸,Burns Karen⁹^ORCID

Affiliation:

1. Division of Hematology/Oncology Department of Pediatrics University of Pittsburgh School of Medicine Pittsburgh Pennsylvania USA

2. UPMC Children's Hospital of Pittsburgh Pittsburgh Pennsylvania USA

3. Division of Hematology/Oncology Department of Pediatrics Indiana University School of Medicine Indianapolis Indiana USA

4. Riley Hospital for Children at Indiana University Health Indianapolis Indiana USA

5. Division of Hematology/Oncology Helen DeVos Children's Hospital, Michigan State University College of Human Medicine Grand Rapids Michigan USA

6. Division of Hematology/Oncology Helen DeVos Children's Hospital Grand Rapids Michigan USA

7. Fred Hutchinson Cancer Center Seattle Children's Hospital Seattle Washington USA

8. Aflac Cancer and Blood Disorders Center Children's Healthcare of Atlanta Pediatric Hematology/Oncology/BMT Emory University Atlanta Atlanta Georgia USA

9. Department of Pediatrics Cancer and Blood Diseases Institute, Cincinnati Children's Hospital Medical Center, University of Cincinnati School of Medicine Cincinnati Ohio USA

Abstract

AbstractThe Oncofertility Consortium Pediatric Initiative Network has published recommendations about the risks of infertility due to gonadotoxic therapy. We abstracted gonadotoxic therapies from central nervous system (CNS) Children's Oncology Group (COG) protocols between 2000 and 2022. We assigned them as unknown, minimal, significant, or high levels of increased risk for gonadal dysfunction/infertility. Seven of 11 CNS protocols placed patients at a high level of risk in at least one treatment arm. Males (7/11) were most commonly at a high level of risk, followed by pubertal females (6/11) and prepubertal females (5/11), highlighting the importance of pre‐treatment counseling regarding fertility preservation interventions in this population.

Funder

National Cancer Institute

National Institutes of Health

St. Baldrick's Foundation

Publisher

Wiley

Link

https://onlinelibrary.wiley.com/doi/pdf/10.1002/pbc.31246

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