Targeted therapies in genetic dilated and hypertrophic cardiomyopathies: from molecular mechanisms to therapeutic targets. A position paper from the Heart Failure Association (HFA) and the Working Group on Myocardial Function of the European Society of Cardiology (ESC)

Author:

de Boer Rudolf A.1,Heymans Stephane23,Backs Johannes45,Carrier Lucie67,Coats Andrew J.S.8,Dimmeler Stefanie91011,Eschenhagen Thomas67,Filippatos Gerasimos12,Gepstein Lior13,Hulot Jean‐Sebastien1415,Knöll Ralph1617,Kupatt Christian18,Linke Wolfgang A.19,Seidman Christine E.202122,Tocchetti C. Gabriele23,van der Velden Jolanda24,Walsh Roddy25,Seferovic Petar M.2627,Thum Thomas2829

Affiliation:

1. Department of Cardiology University Medical Center Groningen, University of Groningen Groningen The Netherlands

2. Department of Cardiology Maastricht University Medical Center (MUMC+) Maastricht The Netherlands

3. Department of Cardiovascular Sciences University of Leuven Leuven Belgium

4. Institute of Experimental Cardiology Heidelberg University Heidelberg Germany

5. German Center for Cardiovascular Research (DZHK), Partner Site Heidelberg/Mannheim Heidelberg Germany

6. Department of Experimental Pharmacology and Toxicology University Medical Center Hamburg‐Eppendorf Hamburg Germany

7. German Centre for Cardiovascular Research (DZHK), partner site Hamburg/Kiel/Lübeck Hamburg Germany

8. Faculty of Medicine University of Warwick Warwick UK

9. Institute for Cardiovascular Regeneration Goethe University Frankfurt Germany

10. German Center for Cardiovascular Research (DZHK) Frankfurt Germany

11. Cardio‐Pulmonary Institute (CPI) Frankfurt Germany

12. Department of Cardiology, National and Kapodistrian University of Athens, School of Medicine Attikon University Hospital Athens Greece

13. Department of Cardiology, Rambam Health Care Campus Technion ‐ Israel Institute of Technology Haifa Israel

14. Université de Paris, INSERM, PARCC Paris France

15. CIC1418 and DMU CARTE, AP‐HP Hôpital Européen Georges‐Pompidou Paris France

16. Department of Medicine, Integrated Cardio Metabolic Centre (ICMC), Heart and Vascular Theme Karolinska Institute Stockholm Sweden

17. Bioscience, Cardiovascular, Renal & Metabolism, BioPharmaceuticals R&D, AstraZeneca Gothenburg Sweden

18. Department of Cardiology University Clinic rechts der Isar, Technical University of Munich, Germany and German Center for Cardiovascular Research (DZHK), Munich Heart Alliance Munich Germany

19. Institute of Physiology II University Hospital Muenster Muenster Germany

20. Department of Genetics Harvard Medical School Boston MA USA

21. Cardiovascular Division, Department of Medicine Brigham and Women's Hospital Boston MA USA

22. Howard Hughes Medical Institute Harvard University Boston MA USA

23. Department of Translational Medical Sciences, Center for Basic and Clinical Immunology Research (CISI); Interdepartmental Center for Clinical and Translational Research (CIRCET); Interdepartmental Hypertension Research Center (CIRIAPA) Federico II University Naples Italy

24. Department of Physiology, Amsterdam UMC, Amsterdam Cardiovascular Sciences Vrije Universiteit Amsterdam Amsterdam The Netherlands

25. Department of Clinical and Experimental Cardiology, Amsterdam UMC, Amsterdam Cardiovascular Sciences University of Amsterdam, Heart Center Amsterdam The Netherlands

26. Serbian Academy of Sciences and Arts Belgrade Serbia

27. Faculty of Medicine University of Belgrade Belgrade Serbia

28. Institute of Molecular and Translational Therapeutic Strategies Hannover Medical School Hannover Germany

29. Fraunhofer Institute for Toxicology and Experimental Medicine Hannover Germany

Publisher

Wiley

Subject

Cardiology and Cardiovascular Medicine

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