Affiliation:
1. Institute of Experimental Hematology Hannover Medical School, Hannover, Germany
2. JRG Translational Hematology of Congenital Diseases, REBIRTH Cluster of Excellence Hannover Medical School, Hannover, Germany
Abstract
Abstract
Since their discovery in 2006, induced pluripotent stem cells (iPSCs) have opened up a world of possibilities for regenerative medicine and novel cell-based therapeutics. Now, over a decade later, robust reprogramming and expansion and differentiation protocols have been developed, and iPSC-derived cells have been used in a wide variety of small and large animal models to treat many different diseases. Furthermore, the first iPSC derivatives are on their way into clinical trials. In this line, (i) GMP-compliant generation, cultivation, and differentiation, (ii) preclinical efficacy and safety, as well as (iii) ethical and regulatory compliance of stem cell research represent important aspects that need to be evaluated for proper clinical translation of iPSCs and their derivatives. In this review article, we provide an overview of the current advances and challenges of the clinical translation of iPSC-derived blood cells and highlight the most pressing problems that have to be overcome in the next years. Stem Cells Translational Medicine 2019;8:332–339
Funder
Deutsche Forschungsgemeinschaft: Cluster of Excellence REBIRTH
Else Kröner-Fresenius-Stiftung
Federal Ministry of Education and Research
Hannover Biomedical Research School, REBIRTH PhD Program “Regenerative Sciences.”
Deutsche Forschungsgemeinschaft
Publisher
Oxford University Press (OUP)
Subject
Cell Biology,Developmental Biology,General Medicine
Cited by
28 articles.
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