Affiliation:
1. Department of Biology, Skeletal Research Center Case Western Reserve University, Cleveland, Ohio, USA
Abstract
Summary
Cell-based therapies have come of age and several phase III trials are now being conducted. Cell-based therapies, especially involving mesenchymal stem cells (MSCs), have substantial nonresponder rates, as has been reported in some current clinical trials. This high rate is expected as the MSCs are neither tuned for each of the diseases that are being treated nor for the huge variance in the genetics and response characteristics of the individual patients being treated. Such nonresponders might be used as a control group, thus eliminating the need for placebo controls.
Funder
Virginia and David Baldwin Fund
National Institutes of Health
Publisher
Oxford University Press (OUP)
Subject
Cell Biology,Developmental Biology,General Medicine
Cited by
26 articles.
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