Anterior Cruciate Ligament Reconstruction in a Rabbit Model Using a Decellularized Allogenic Semitendinous Tendon Combined with Autologous Bone Marrow-Derived Mesenchymal Stem Cells-Reference-Cited by-同舟云学术

Anterior Cruciate Ligament Reconstruction in a Rabbit Model Using a Decellularized Allogenic Semitendinous Tendon Combined with Autologous Bone Marrow-Derived Mesenchymal Stem Cells

Published:2019-05-11 Issue:9 Volume:8 Page:971-982
ISSN:2157-6564
Container-title:Stem Cells Translational Medicine
language:en
Short-container-title:

Author:

Lu Wei¹,Xu Jian¹,Dong Shikui²,Xie Guoming²,Yang Shuanghui³,Huangfu Xiaoqiao²,Li Xiaoxi²,Zhang Yang²,Shen Peng²,Yan Zhaowen⁴,Liu Haifeng¹,Deng Zhenhan¹,Zhao Jinzhong²

Affiliation:

1. Department of Sports Medicine the First Affiliated Hospital of Shenzhen University, Shenzhen Second People's Hospital, Shenzhen, China

2. Department of Arthroscopic Surgery Shanghai Jiao Tong University Affiliated Sixth People's Hospital, Shanghai, China

3. Department of Hematology Xiangya Hospital, Central South University, Changsha, China

4. Department of Pathology Shanghai Jiao Tong University School of Medicine, Shanghai, China

Abstract

Abstract As a regular adoptable material for anterior cruciate ligament (ACL) reconstruction, free tendon allograft exhibits unsatisfactory outcomes, such as retarded ligamentization and tendon–bone integration. The application of bone marrow-derived mesenchymal stem cells (BMSCs), as well as a decellularized free tendon allograft developed by our group, was proven to be effective in improving ACL reconstruction results. This study aimed to investigate the efficacy and feasibility of decellularized allogenic semitendinous tendon (ST) combined with autologous BMSCs used as a substitute to free tendon allograft in a rabbit model. This study finally shows that the decellularized allogenic ST combined with autologous BMSCs could significantly improve ACL reconstruction results compared with allograft. Stem Cells Translational Medicine 2019;8:971–982

Funder

National Natural Science Foundation of China

Publisher

Oxford University Press (OUP)

Subject

Cell Biology,Developmental Biology,General Medicine

Link

https://onlinelibrary.wiley.com/doi/pdf/10.1002/sctm.18-0132

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