Optimization of extraction and analytical protocol for mass spectrometry-based metabolomics analysis of hepatotoxicity

Author:

Yang Rui12,Zhao Qi12,Hu Dan-Dan13,Xiao Xue-Rong1,Li Fei1ORCID

Affiliation:

1. State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany; Chinese Academy of Sciences; Kunming China

2. University of Chinese Academy of Sciences; Beijing China

3. School of Pharmaceutical Science and Yunnan Key Laboratory of Pharmacology of Natural Products; Kunming Medical University; Kunming China

Funder

National Key Research and Development Program of China

CAS “Light of West China” Program

Kunming Institute of Botany, Chinese Academy of Sciences

Thousand Young Talents Program of China

State Key Laboratory of Phytochemistry and Plant Resources in West China

Publisher

Wiley

Subject

Clinical Biochemistry,Drug Discovery,Pharmacology,Molecular Biology,General Medicine,Biochemistry,Analytical Chemistry

Reference41 articles.

1. The metabolomic window into hepatobiliary disease;Beyoglu;Journal of Hepatology,2013

2. Optimization of harvesting, extraction, and analytical protocols for UPLC-ESI-MS-based metabolomic analysis of adherent mammalian cancer cells;Bi;Analytical and Bioanalytical Chemistry,2013

3. Targeted metabolomics of serum acylcarnitines evaluates hepatoprotective effect of Wuzhi Tablet (schisandra sphenanthera extract) against acute acetaminophen toxicity;Bi;Evidence-based Complementary and Alternative Medicine,2013

4. Use of toxicogenomics to understand mechanisms of drug-induced hepatotoxicity during drug discovery and development;Blomme;Toxicology Letters,2009

5. Dietary nucleotides supplementation and liver injury in alcohol-treated rats: A metabolomics investigation;Cai;Molecules,2016

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