Identification ofIRX1as a Risk Locus for Rheumatoid Factor Positivity in Rheumatoid Arthritis in a Genome-Wide Association Study

Author:

Julià Antonio1,Blanco Francisco2,Fernández-Gutierrez Benjamín3,González Antonio4ORCID,Cañete Juan D.5,Maymó Joan6,Alperi-López Mercedes7,Olivè Alex8,Corominas Héctor9,Martínez-Taboada Víctor10,González-Álvaro Isidoro11,Fernandez-Nebro Antonio12,Erra Alba13,Sánchez-Fernández Simón14,Alonso Arnald1,López-Lasanta María1,Tortosa Raül1,Codó Laia15,Lluis Gelpi Josep15,García-Montero Andrés C.16,Bertranpetit Jaume17,Absher Devin18,Myers Richard M.18,Tornero Jesús19,Marsal Sara1

Affiliation:

1. Vall d'Hebron Hospital Research Institute; Barcelona Spain

2. Instituto de Investigación Biomédica de A Coruña-Hospital Universitario A Coruña; A Coruña Spain

3. Hospital Clínico San Carlos; Madrid Spain

4. Instituto de Investigación Sanitaria and Hospital Clinico Universitario de Santiago; Santiago de Compostela Spain

5. Hospital Clínic de Barcelona; Barcelona Spain

6. Hospital del Mar; Barcelona Barcelona Spain

7. Hospital Universitario Central de Asturias; Oviedo Spain

8. Hospital Universitari Germans Trias i Pujol; Barcelona Spain

9. Hospital Moisès Broggi; Barcelona Spain

10. Hospital Universitario Marqués de Valdecilla; Santander Spain

11. Hospital Universitario La Princesa, IIS Princesa; Madrid Spain

12. Instituto de Investigación Biomédica de Málaga, Hospital Regional Universitario de Málaga, and Universidad de Málaga; Málaga Spain

13. Hospital Sant Rafael; Barcelona Spain

14. Hospital General La Mancha Centro; Ciudad Real Spain

15. Barcelona Supercomputing Center; Barcelona Spain

16. National DNA Bank Carlos III and University of Salamanca; Salamanca Spain

17. National Genotyping Center and Pompeu Fabra University; Barcelona Spain

18. HudsonAlpha Institute for Biotechnology; Huntsville Alabama

19. Hospital Universitario de Guadalajara; Guadalajara Spain

Funder

Spanish Ministry of Economy and Competitiveness

Publisher

Wiley

Subject

Immunology,Rheumatology,Immunology and Allergy

Reference49 articles.

1. Evolving concepts of rheumatoid arthritis;Firestein;Nature,2003

2. The American Rheumatism Association 1987 revised criteria for the classification of rheumatoid arthritis;Arnett;Arthritis Rheum,1988

3. Rheumatoid factor isotypes in monozygotic and dizygotic twins discordant for rheumatoid arthritis;MacGregor;J Rheumatol,1995

4. Associations of HLA-DR4 with rheumatoid factor and radiographic severity in rheumatoid arthritis;Olsen;Am J Med,1988

5. Differential agglutination of normal and sensitized sheep erythrocytes by sera of patients with rheumatoid arthritis;Rose;Proc Soc Exp Biol Med,1948

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