A Temperature‐Sensing Hydrogel Coating on The Medical Catheter

Author:

Li Yiran1ORCID,Li Dan2ORCID,Wang Jiacheng1ORCID,Ye Tingting1ORCID,Li Qianming1ORCID,Li Luhe1ORCID,Gao Rui1ORCID,Wang Yuanzhen1ORCID,Ren Junye1ORCID,Li Fangyan1ORCID,Lu Jiang1ORCID,He Er1ORCID,Jiao Yiding1ORCID,Wang Lie1ORCID,Zhang Ye1ORCID

Affiliation:

1. National Laboratory of Solid State Microstructures Jiangsu Key Laboratory of Artificial Functional Materials Chemistry and Biomedicine Innovation Center Collaborative Innovation Center of Advanced Microstructures College of Engineering and Applied Sciences Nanjing University Nanjing 210023 China

2. Key Laboratory of Inflammation and Immunoregulation School of Medicine and Holistic Integrative Medicine Nanjing University of Chinese Medicine Nanjing 210023 China

Abstract

AbstractMedical surgical catheters are widely used in the medical field for drug delivery or postoperative drainage. However, infections associated with local temperature rise often occur at the catheter‐tissue interface, resulting in irreversible pathological damage, cognitive behavioral abnormalities, or even an increased risk of mortality if not monitored in time. Herein, an in situ temperature‐sensing hydrogel coating on the outer surface of medical surgical catheters for real‐time infection monitoring is developed. The hydrogel coating exhibits a record temperature coefficient of resistance of 2.90%  °C−1 and maintains stable in vivo. Besides, the hydrogel layer forms a mechanically compatible catheter‐tissue interface and minimizes the risk of inflammatory responses due to its tissue‐like softness (Young's modulus of 4.24 kPa). By applying it in the early detection of infections in the brain of SD rats, the individual survival rate has increased to 90% with timely intervention.

Funder

National Natural Science Foundation of China

Natural Science Foundation of Jiangsu Province

China Postdoctoral Science Foundation

Publisher

Wiley

Subject

Electrochemistry,Condensed Matter Physics,Biomaterials,Electronic, Optical and Magnetic Materials

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