Ultra‐Sensitive and Unlabeled SERS Nanosheets for Specific Identification of Glucose in Body Fluids

Author:

Zhang Ting12ORCID,Li Yuting1,Lv Xiaoming1,Jiang Shen1,Jiang Shuang1,Sun Zhongqi1,Zhang Mingxu1,Li Yang134ORCID

Affiliation:

1. State Key Laboratory of Frigid Zone Cardiovascular Diseases (SKLFZCD), Research Center for Innovative Technology of Pharmaceutical Analysis College of Pharmacy Harbin Medical University Heilongjiang 150081 P. R. China

2. Department of Inorganic Chemistry and Physical Chemistry College of Pharmacy Harbin Medical University Heilongjiang 150081 P. R. China

3. Traditional Chinese Medicine Department of the Second Affiliated Hospital Harbin Medical University Heilongjiang 150081 P. R. China

4. Research Unit of Health Sciences and Technology (HST) Faculty of Medicine University of Oulu Oulu 90014 Finland

Abstract

AbstractThe detection of biomolecules utilizing surface‐enhanced Raman spectroscopy (SERS) is highly trending in research, but the unlabeled and sensitive detection of saccharides in body fluids is challenging. Here, a novel SERS substrate (AgNS600) is fabricated by physical scratching of smooth silver sheets, which successfully achieves enhanced SERS fingerprinting by capturing glucose molecules through nanoscale grooves on the surface of the substrate to form multi‐dimensional “hot spot” regions. The platform proves to be rapid, reliable, and reproducible, with a lower detection limit of 0.5 amol L−1 in deionized water. Further detection of multiple monosaccharides, polysaccharides, and mix samples, which are distinguished with machine learning and heat map, demonstrates the versatility and specificity of the platform. Importantly, real samples are explored and the results show that the platform is able to detect and recognize SERS signals of glucose in the blood, urine, tears, and perspiration, and non‐destructive predict diabetes by analyzing the signal intensity of different characteristic peaks. In this work, it is the first non‐chemical, unlabeled determination of glucose with high sensitivity via SERS, which provides a potential strategy for advancing the clinical development of SERS technology and the early diagnosis of glucose metabolic diseases.

Publisher

Wiley

Subject

Electrochemistry,Condensed Matter Physics,Biomaterials,Electronic, Optical and Magnetic Materials

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