Au/FeNiPO4‐Based Multiple Spectra Optoacoustic Tomography/CT Dual‐Mode Nanoprobe for Systemic Screening of Atherosclerotic Vulnerable Plaque

Author:

Cai Jiageng12,Ge Xiaoxiao3,Lu Shiyu1,Wang Yabin4,Cui Hongtu125,Zhan Rui6,Su Sheng'e27,Shan Wenxin27,Cai Zhulan12,Wu Cencen12,Xu Yuan12,Zhao Penghui12,Li Yanyan8,Lan Yue27,Sun Le3,Guo Shaojun1,Zheng Lemin27,Zu Lingyun12ORCID

Affiliation:

1. Department of Cardiology and Institute of Vascular Medicine Peking University Third Hospital Department of Materials Science and Engineering Peking University Beijing 100871 China

2. State Key Laboratory of Vascular Homeostasis and Remodeling NHC Key Laboratory of Cardiovascular Molecular Biology and Regulatory Peptides Beijing Key Laboratory of Cardiovascular Receptors Research Peking University Beijing 100191 China

3. Beijing Institute Brain Disorders Capital Medical University Beijing 100069 China

4. Department of Cardiology & National Clinical Research Center of Geriatrics Disease Chinese PLA General Hospital Beijing 100853 China

5. Research Unit of Medical Science Research Management/Basic and Clinical Research of Metabolic Cardiovascular Diseases Chinese Academy of Medical Sciences Beijing 100191 China

6. Research Center for Cardiopulmonary Rehabilitation University of Health and Rehabilitation Sciences Qingdao Hospital (Qingdao Municipal Hospital) School of Health and Life Sciences University of Health and Rehabilitation Sciences Qingdao 266071 China

7. The Institute of Cardiovascular Sciences and Institute of Systems Biomedicine School of Basic Medical Sciences Health Science Center Peking University Beijing 100191 China

8. School of Bioscience and Technology Shandong Second Medical University Weifang 261053 China

Abstract

AbstractCurrent diagnostic technique in direct identification of multi‐site plaques and simultaneous assessment of plaque vulnerability remains a challenge, which is crucial for indicating the risk of atherosclerotic cardiovascular diseases (ASCVD). Herein, an osteopontin (OPN)‐specific nanoprobe (OPN Ab‐Au/FeNiPO4@ICG) with both multiple spectra optoacoustic tomography (MSOT) and computed tomography (CT) imaging, is constructed successfully realizing systemic screening of vulnerable plaque. OPN Ab‐Au/FeNiPO4@ICG nanoprobe specifically targeted OPN‐overexpressed foam cells and recognized the vulnerable plaque at the molecular level. In AS mice, CT imaging exhibits that OPN Ab‐Au/FeNiPO4@ICG nanoprobe effectively avoid interference from calcification and accurately visualized AS plaque. MSOT functional imaging results reveals that after the injection of OPN Ab‐Au/FeNiPO4@ICG nanoprobe, the carotid plaque exhibited a much higher MSOT signal than the aortic arch plaque (P = 0.0291). Further pathological analysis displays that the carotid plaque possessed a much higher vulnerability score (P = 0.0247), in agreement with the MSOT signals. More importantly, the linear regression analysis confirms the high correlation between the MSOT signals and plaque vulnerability with R = 0.7095 (P = 0.0216), demonstrating the potential of the proposed nanoprobe in systematic evaluation of plaque vulnerability. This work employs the dual‐model nanoprobe strategy for both plaque localization and vulnerability assessment, greatly advancing the accurate diagnosis of ASCVD.

Funder

National Key Research and Development Program of China

National Natural Science Foundation of China

Publisher

Wiley

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