Bioinspired Multiantioxidant‐Cooperative Nanotheranostic Platform for Realizing Time‐Sensitive Management of Acute Kidney Injury

Author:

Wu Menglin1,Lu Li2,Li Jiang1,Guo Qi1,Wang Daohan2,Gong Yan3,Wu Xinhong1,Zhao Xunxiao1,Zhang Xuening1,Zhao Yang14,Li Xue1ORCID

Affiliation:

1. Department of Radiology The Second Hospital of Tianjin Medical University Tianjin 300211 China

2. Department of General Surgery The General Hospital of Tianjin Medical University Tianjin 300052 China

3. Department of Radiology Tianjin Medical University Nankai Hospital Tianjin 300100 China

4. Tianjin Institute of Urology The Second Hospital of Tianjin Medical University Tianjin 300211 China

Abstract

AbstractTargeting the pivotal pathological processes of acute kidney injury (AKI) and parallelly monitoring the treatment process has emerged as an intriguing strategy for the timely tailored treatment of AKI, especially in the acute phase. Unfortunately, current clinical treatment approaches are restricted to supportive care, which shows limited efficiency. Herein, a multiantioxidant‐cooperative polydopamine‐based nanotheranostic platform (mc‐PDATP) is reported to achieve imaging‐assisted time‐sensitive therapy of AKI. Benefiting from the decoration of atomic Cu, mc‐PDATP comprehensively mimics the complicated antioxidant defense system as in natural environment, thus displaying improved catalytic activity to multiple toxic reactive oxygen species (ROS). Consequently, both in vitro and in vivo experiments confirm mc‐PDATP can efficiently protect the kidney from ROS attack and rescue the kidney function via targeting the inflammatory network of AKI. In addition, the coordinated atomic Gd contributes to a desired magnetic resonance (MR) T1‐weighted contrast effect of mc‐PDATP, which can be used to construct the sensitive MR histogram imaging signatures for pinpointing treatment effects in a timely manner. The study represents an innovative strategy for anti‐AKI therapy, which will facilitate the development of next‐generation theranostic nano‐antioxidants.

Funder

National Natural Science Foundation of China

Natural Science Foundation of Tianjin City

Publisher

Wiley

Subject

Electrochemistry,Condensed Matter Physics,Biomaterials,Electronic, Optical and Magnetic Materials

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