Affiliation:
1. Department of Breast Surgery Shanghai Jiao Tong University School of Medicine Xinhua Hospital Shanghai 200092 China
2. Chongming Hospital Affiliated to Shanghai University of Medicine and Health Sciences Shanghai 200093 China
3. Department of Clinical Pharmacy Shanghai Jiao Tong University School of Medicine Xinhua Hospital Shanghai 200092 China
4. School of Materials and Chemistry University of Shanghai for Science and Technology Shanghai 200093 China
5. Clinical Pharmacy Innovation Institute Shanghai Jiao Tong University School of Medicine Shanghai 200092 China
Abstract
AbstractTriple‐negative breast cancer (TNBC), a highly aggressive form of breast cancer, currently lacks targeted therapies and is associated with high recurrence rates in medical practice. In this study, the effectiveness of a specially developed magnetic nanodrug, namely doxorubicin (DOX)‐loaded Fe3O4 vortex magnetic nanoannulars coated with a cancer cell membrane (DOX‐VMAs@CM), against cancer under a varying low‐frequency magnetic field (MF), is investigated. This advanced nanodrug can specifically target and accumulate in tumors. Additionally, it considerably improves tumor suppression compared with that of DOX chemotherapy alone, indicating the possibility of homologous targeting of the cancer cell membrane and the vibrating effect of the MF. The DOX‐VMAs@CM nanoparticles (NPs) exhibit exceptional safety characteristics because of their ability to specifically target tumors. The results of RNA sequencing suggest that the potential mechanisms may involve cellular respiration, cell cycle, and ferroptosis regulation. Altogether, chemotherapy is successfully optimized by implementing a delivery system and MF intervention, and the developed DOX‐VMAs@CM NPs hold significant potential for use in the clinical treatment of TNBC.
Funder
National Natural Science Foundation of China
Science and Technology Commission of Shanghai Municipality