Affiliation:
1. Department of Thyroid and Breast Surgery, Zhongnan Hospital of Wuhan University, School of Pharmaceutical Sciences Wuhan University Wuhan 430071 China
2. Key Laboratory of Combinatorial Biosynthesis and Drug Discovery (Ministry of Education) School of Pharmaceutical Sciences Wuhan University Wuhan 430071 China
3. Department of Pharmacy, Union Hospital Tongji Medical College, Huazhong University of Science and Technology Wuhan 430022 China
4. Clinical Trial Center Zhongnan Hospital of Wuhan University Wuhan 430071 China
Abstract
AbstractThe design and fabrication of artificial receptors suitable for highly selective and sensitive sensing of neurotransmitters in aqueous media remains a challenge, especially for the significant biomarker dopamine (DA) for neurological diseases. Herein, a novel modular fluorescent artificial receptor design strategy based on multiple parameters programming engineering is proposed. The optimal artificial receptor DA biosensor based on fluorescent lanthanide metal‐organic frameworks (Ln‐MOFs) is coded by adjusting the modular design parameters such as preparation solvents and ligands. It is prepared by Eu ion and ligand 1,2,4,5‐benzenetetracarboxylic acid (BTEC) in DMF/water, which can selectively recognize DA even in complex biological fluids, without the interference of other structurally similar neurotransmitters such as levodopa, serotonin and noradrenaline, and the limit of detection for DA is as low as 10 nm. Ln‐MOFs are believed to uniquely utilize their tunable host‐guest interactions (specific recognition) and confinement catalysis capabilities to achieve highly selective and dual‐response DA detection, similar to lock‐and‐key theory, which is supported by experiments and density functional theory calculations. Fluorescent artificial receptors based on Ln‐MOFs are proved to have broad potential for label‐free detection, imaging and diagnosis. They can overcome the long‐standing limitations of complex synthetic biosensors, and bringing new solutions to personalized medicine.
Funder
National Natural Science Foundation of China
Fundamental Research Funds for the Central Universities
Subject
Electrochemistry,Condensed Matter Physics,Biomaterials,Electronic, Optical and Magnetic Materials
Cited by
25 articles.
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