Bionic Mineralized 3D‐Printed Scaffolds with Enhanced In Situ Mineralization for Cranial Bone Regeneration

Author:

Wang Ling12ORCID,Li Dongxuan12,Huang Yawen12,Mao Ruiqi3,Zhang Boqing12,Luo Fengxiong12,Gu Peiyang12,Song Ping12,Ge Xiang4,Lu Jian12,Yang Xusheng5,Fan Yujiang12,Zhang Xingdong12,Wang Kefeng12ORCID

Affiliation:

1. National Engineering Research Center for Biomaterials Sichuan University Chengdu Sichuan 610064 China

2. College of Biomedical Engineering Sichuan University Chengdu Sichuan 610064 China

3. College of Materials Science and Engineering Sichuan University Chengdu Sichuan 610064 China

4. Key Laboratory of Mechanism Theory and Equipment Design of Ministry of Education School of Mechanical Engineering Tianjin University Tianjin 300354 China

5. Department of Industrial and Systems Engineering Research Institute for Advanced Manufacturing The Hong Kong Polytechnic University Hung Hom Kowloon Hong Kong 100872 China

Abstract

AbstractIn situ mineralization is a promising strategy to mimic the physicochemical properties of biominerals and is widely applied in the field of bone repair. Given the high requirement for substance exchange in cranial bone regeneration, in situ mineralized organic–inorganic hybrid materials exhibit advantages. However, the integration of remarkable mineral content, mechanical properties, and osteogenic properties also remains a major challenge. Herein, enhanced in situ mineralization through combining the enzymatic and anion‐boosted mineralization is applied to promote the mineralization efficiency, mineral content, and mechanical properties. Based on the results of computational calculations and in vitro mineralization experiments, the mechanism of mineralization enhancement is investigated from the perspectives of nucleation sites and the saturation of in situ mineralization. Anionic polyaspartic acid (pAsp) can increase the saturation of in situ mineralization; enzymatic mineralization shows high efficiency, with minerals of low crystallinity. The changes in the properties of the minerals effectively enhance the biological properties of 3D‐printed scaffolds, as confirmed by cell proliferation/differentiation experiments in vitro and in cranial bone regeneration in vivo. This strategy provides a new thinking for the preparation of bionic mineralized scaffolds for cranial bone repair, and can greatly promote the efficiency of bone regeneration.

Funder

Chengdu Municipal Science and Technology Program

Natural Science Foundation of Tianjin Municipality

National Natural Science Foundation of China

Natural Science Foundation of Sichuan Province

Key Technologies Research and Development Program

Publisher

Wiley

Subject

Electrochemistry,Condensed Matter Physics,Biomaterials,Electronic, Optical and Magnetic Materials

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