Affiliation:
1. School of Materials and Environmental Engineering Shenzhen Polytechnic University Shenzhen 518055 P. R. China
2. Department of Biomedical Engineering Guangdong Provincial Key Laboratory of Advanced Biomaterials Institute of Innovative Materials Southern University of Science and Technology Shenzhen 518055 P. R. China
3. Munich Institute of Biomedical Engineering Department of Electrical Engineering TUM School of Computation, Information and Technology Technical University of Munich Hans‐Piloty‐Str. 1 85748 Garching Germany
Abstract
AbstractBiological‐machine interface (BMI) devices represent a significant step toward adaptive and cognitive technologies. However, current BMI devices emphasize the analysis of electrophysiology and often overlook the chemical information of neurotransmitters in the process of signaling between neurons. To bridge this gap, a light‐gated artificial postsynaptic membrane (APM) is introduced, capable of reading dopamine (DA) released from rat pheochromocytoma cells and regulate neural signal transmission. Like the biological postsynaptic membrane, the APM is a porous membrane functionalized by DA‐specific aptamers and azobenzene (Azo) molecules in different regions. Azo molecules act as a light‐responsive trigger that controls DA release, while DA‐specific aptamers capture DA, which converts its concentration information into an ionic current signal. By light‐enhanced responses to DA exocytosis from rat pheochromocytoma (PC12) cells, the APM confirms its ability to communicate with biological systems, which lays the foundation for developing biological‐machine interaction systems with more advanced functionalities.
Funder
National Natural Science Foundation of China