Affiliation:
1. Department of Rheumatology and Immunology Nanjing Drum Tower Hospital Clinical College of Nanjing University of Chinese Medicine Nanjing 210023 China
2. State Key Laboratory of Bioelectronics School of Biological Science and Medical Engineering Southeast University Nanjing 210096 China
Abstract
AbstractIn diabetic wound healing, M1 macrophage accumulation and elevated inflammation are prevalent issues. Intelligent delivery systems that can sustainably release antioxidizing and anti‐inflammatory ingredients are expected for effective wound healing. Herein, a novel glycyrrhetinic acid (GA) liposomes encapsulated microcapsules delivery system that has desired features for inflammatory wound repair is presented. As the bacteria could break down the alginate shells, the GA liposomes could be controllably released from the microcapsules, which promotes M2 macrophage polarization and regulate their responses in the inflammatory wound microenvironment. Based on these, it is demonstrated that the GA liposomes encapsulated microcapsules delivery system exhibits an anti‐inflammatory and immunomodulatory effect for diabetic wound healing in a full‐thickness defect model in diabetic rats. These results indicate that the immunomodulatory capabilities of the microcapsules can be unitized for efficient wound repair, and such a delivery system is valuable for clinical wound healing applications.
Funder
National Key Research and Development Program of China
National Natural Science Foundation of China
Nanjing Medical Science and Technique Development Foundation
Shenzhen Fundamental Research Program
Subject
Electrochemistry,Condensed Matter Physics,Biomaterials,Electronic, Optical and Magnetic Materials