Affiliation:
1. Guangdong Provincial Key Laboratory of Tumor Interventional Diagnosis and Treatment Zhuhai People's Hospital, Zhuhai Hospital Affiliated with Jinan University Jinan University Zhuhai Guangdong 519000 P. R. China
2. Department of Chemistry Institute of Food Safety and Nutrition, State Key Laboratory of Bioactive Molecules and Druggability Assessment Jinan University Guangzhou 510632 P. R. China
3. Key Laboratory of Organosilicon Chemistry and Material Technology of Ministry of Education Hangzhou Normal University Hangzhou 311121 P. R. China
Abstract
AbstractRadiotherapy, as one of the most common strategies for clinical cancer treatment, suffers from failure due to the hypoxia, inflammation, and radiosensitivity difference of malignant tumors, side effects, and radioresistance. Heterojunction‐based radiosensitizers attract great attention to the lower excitation energy and remarkable catalytic activity as compared to typical transition metal radiosensitizers. However, the bio‐application of heterojunction radiosensitizers is in its infancy due to the challenges in structure engineering, rational energy band alignment, and ideal photogenerated carrier migration. Herein, a bimetallic metal‐organic framework (MOF)‐based heterojunction radiosensitizer is reasonably designed to enhance the radiodynamic therapeutic efficiency of Ru complex, and to activate natural killer (NK) cell‐mediated innate immune responses for promoted tumor immunotherapy. This study not only designs a novel bimetallic MOF‐based heterojunction structure but also elucidates the underlying action mechanisms in inhibiting cancer proliferation, which sheds light on the practicable design of radiosensitizers and the tumor combination treatment.
Funder
National Natural Science Foundation of China
National Science Fund for Distinguished Young Scholars
Subject
Electrochemistry,Condensed Matter Physics,Biomaterials,Electronic, Optical and Magnetic Materials