Affiliation:
1. State Key Laboratory of Fluid Power and Mechatronic Systems Key Laboratory of 3D Printing Process and Equipment of Zhejiang Province School of Mechanical Engineering Zhejiang University Hangzhou 310027 China
2. The Affiliated Hospital of Stomatology School of Stomatology Zhejiang University Hangzhou 310006 China
3. Key Laboratory of Materials Processing and Mold Zhengzhou University Zhengzhou 450002 China
4. Cancer Center Zhejiang University Hangzhou 310058 China
Abstract
AbstractBio‐ink has gradually transited from ionic‐crosslinking to photocrosslinking due to photocurable bio‐hydrogel having good formability and biocompatibility. It is very important to understand and quantify the crosslinking process of photocurable hydrogels, otherwise, bioprinting cannot be standardized and scalable. However, there are few studies on hydrogel formation process and its photocrosslinking behavior which cannot be accurately predicted. Herein, the photoinitiated radical polymerized bio‐hydrogels are taken as an example to establish the formation theory. Three typical crosslinking reactions are first distinguished. It is further proposed that not all double‐bonds consumed during crosslinking contributeequally to polymerization. Then the concept of effective double‐bond conversion (EDBC) is elicited. Deriving from EDBC, several important formation indices are defined. According to theory, it is predicted that slow crosslinking can improve the crosslinking degree. Furthermore, based on the slow crosslinking effect, a new strategy of projection‐based 3D printing (PBP) is proposed, which significantly improved printing quality and efficiency. Overall, this work will fill the gap in hydrogel's formation theory, making it possible to accurately quantify the formation process.
Funder
National Key Research and Development Program of China
National Natural Science Foundation of China
Subject
Electrochemistry,Condensed Matter Physics,Biomaterials,Electronic, Optical and Magnetic Materials
Cited by
2 articles.
订阅此论文施引文献
订阅此论文施引文献,注册后可以免费订阅5篇论文的施引文献,订阅后可以查看论文全部施引文献