Affiliation:
1. Institute of Medical Engineering Department of Biophysics School of Basic Medical Science Health Science Center Xi'an Jiaotong University No. 76 Yanta West Road Xi'an Shaanxi 710061 P. R. China
2. School of Public Health Health Science Center Xi'an Jiaotong University No.76 Yanta West Road Xi'an Shaanxi 710061 P. R. China
3. Institute of Functional Nano & Soft Materials (FUNSOM) Jiangsu Key Laboratory for Carbon‐Based Functional Materials and Devices Soochow University Suzhou 215123 P. R. China
4. Department of Radiology Memorial Sloan Kettering Cancer Center New York NY 10065 USA
Abstract
AbstractSonodynamic therapy (SDT), which uses ultrasound to trigger a sonosensitizer to generate reactive oxygen species (ROS), is a promising form of cancer therapy with outstanding tissue penetration depth. However, the sonosensitizer may inevitably spread to surrounding healthy tissue beyond the tumor, resulting in undesired side effects under an ultrasound stimulus. Herein, as glutathione (GSH) is overexpressed in the tumor microenvironment, a GSH‐activatable sonosensitizer prodrug is designed by attaching a quencher to tetraphydroxy porphyrin for tumor therapy. The prodrug exhibits poor fluorescence and low ROS generation capacity under ultrasound irradiation, but it also showed that it can be activated by GSH to simultaneously switch on fluorescence emission and ROS generation capability at the tumor site. Compared with the non‐quenched sonosensitizer, the designed prodrug exhibits significantly higher tumor/healthy organ fluorescence ratios, due to the specific fluorescence and ROS activation by overexpressed GSH in the tumor. Finally, the prodrug exhibits efficient tumor growth inhibition under ultrasound irradiation, further demonstrating its promise as a GSH‐activated sonosensitizer prodrug for highly effective cancer treatment.
Funder
National Natural Science Foundation of China
Natural Science Foundation of Shaanxi Province
Subject
Electrochemistry,Condensed Matter Physics,Biomaterials,Electronic, Optical and Magnetic Materials
Cited by
7 articles.
订阅此论文施引文献
订阅此论文施引文献,注册后可以免费订阅5篇论文的施引文献,订阅后可以查看论文全部施引文献