Affiliation:
1. Technology Innovation Center of Mass Spectrometry for State Market Regulation Center for Advanced Measurement Science National Institute of Metrology Beijing 100029 P. R. China
2. MOE Key Laboratory of Bioorganic Phosphorus Chemistry & Chemical Biology Department of Chemistry Laboratory of Flexible Electronics Technology Center for Synthetic and Systems Biology Tsinghua University‐Peking University Joint Centre for Life Sciences Tsinghua University Beijing 100084 P. R. China
Abstract
AbstractArtificial cells are synthetic constructs that emulate natural cells, with potential applications in areas of energy science, environmental treatment, and the study of life's origins. Nevertheless, the construction of artificial cells is a formidable undertaking, given the intricate nature of natural cells in structures, functions, and working mechanisms. With precise control, high automation, and excellent uniformity, microfluidics has emerged as a promising approach for the construction of artificial cells. This review summarizes the latest microfluidic techniques utilized to construct artificial cells, ranging from simple droplets to sophisticated cell‐inspired systems. These include the generation of droplets, the production of vesicles (lipid‐based and polymer‐based vesicles), the fabrication of polymeric microparticles with various compartments, shapes, and microstructures, as well as the manufacture of sophisticated cell‐inspired systems. The characteristics of different methods for the construction of artificial cells are discussed in detail. Furthermore, the wide‐ranging applications of artificial cells are also showcased. Finally, contemporary obstacles and forthcoming advancements are discussed in the field of microfluidic‐based artificial cells. This review is supposed to stimulate research in the construction of more functional and natural‐like artificial cells, as well as works in the fields of material, biology, environment, medicine, and energy.
Funder
National Natural Science Foundation of China
National Key Research and Development Program of China
Key Technologies Research and Development Program
Subject
Electrochemistry,Condensed Matter Physics,Biomaterials,Electronic, Optical and Magnetic Materials
Cited by
1 articles.
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