A Self‐Gelling Powder Directly Co‐Assembled by Natural Small Molecules for Traumatic Brain Injury

Author:

Yang Shutong1,Luo Weikang234,Song Xianwen5,Chen Quan234,Liu Jingjing234,Gan Pingping6,Liu Chuntai7,Li Teng234,Xu Gang8,Zhang Yi1ORCID,Zheng Jun234,Wang Yang234

Affiliation:

1. Hunan Provincial Key Laboratory of Micro and Nano Materials Interface Science College of Chemistry and Chemical Engineering Central South University Changsha 410083 P. R. China

2. Institute of Integrative Medicine Department of Integrated Traditional Chinese and Western Medicine Xiangya Hospital Central South University Changsha 410008 P. R. China

3. Center for Interdisciplinary Research in Traditional Chinese Medicine Xiangya Hospital Central South University Changsha 410008 P. R. China

4. National Clinical Research Center for Geriatric Disorders Xiangya Hospital Central South University Changsha 410008 P. R. China

5. Engineering Research Center of Ministry of Education Guangxi University of Chinese Medicine Nanning 530200 P. R. China

6. Department of Oncology Xiangya Hospital Central South University Changsha 410008 P. R. China

7. College of Materials Science and Engineering Zhengzhou University Zhengzhou 450001 P. R. China

8. Hunan Flag Biotechnology Co., Ltd Changsha 410100 P. R. China

Abstract

AbstractThe prognosis for traumatic brain injury (TBI) depends largely on prompt hemostasis and effective pharmacologic interventions. Natural all‐small‐molecule self‐gelling powder, integrating the advantages of self‐assembled small‐molecule hydrogels and powders, is expected to provide timely and effective prehospital management of TBI. However, the synthesis and application of natural all‐small‐molecule self‐gelling powder is still uncharted territory. In this study, an all‐small‐molecule co‐assembled MGF‐H3BO3‐RUT (MBR) self‐gelling powder is fabricated through the co‐assembly of mangiferin (MGF) and rutin (RUT) in H3BO3/NaOH aqueous solution. Both compounds can bind with boric acid, leading to co‐assembling into hydrogels through hydrogen‐bonding interactions and ππ stacking. MBR self‐gelling powder is then obtained by drying the as‐prepared hydrogels, thus integrating hemostasis and pharmacodynamics into one. Remarkably, it displays robust regeneration capabilities, while retaining excellent self‐healing properties and injectability after drying‐hydration cycles. Moreover, MBR self‐gelling powder not only achieves rapid effective hemostasis but also attenuates conspicuously cerebral edema and inflammatory response after TBI by in situ spraying, exhibiting notable neuroprotective effects without discernible toxic side effects. This study provides a novel assembly strategy and application form for self‐assembled gel materials originating from natural small molecules, offering promising avenues for the treatment of TBI in the acute phase.

Funder

Fundamental Research Funds for Central Universities of the Central South University

Key Research and Development Program of Hunan Province of China

National Natural Science Foundation of China

Publisher

Wiley

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