On‐Patient Temporary Medical Record for Accurate, Time‐Sensitive Information at the Point of Care

Author:

Collins Joe1,Han Jooli1,Sarmadi Morteza123,Allison‐Logan Stephanie4,Straeten Aurelien vander1,Perkinson Collin F.5,Acolaste Sarah1,Kanelli Maria1,Daristotle John1,Karchin Ari6,Henderson Mitchell6,Cruz Mache1,Artzi Dolev1,Alsaiari Shahad K.1,Zhang Linzixuan7,Levy Lauren8,Wood Lowell6,Jing Lihong9,McHugh Kevin J.1011,Bawendi Moungi G.5,Langer, Robert1237ORCID,Jaklenec Ana1ORCID

Affiliation:

1. Koch Institute for Integrative Cancer Research Massachusetts Institute of Technology Cambridge MA 02139 USA

2. Department of Mechanical Engineering Massachusetts Institute of Technology Cambridge MA 02139 USA

3. Harvard‐MIT Division of Health Sciences and Technology Institute for Medical Engineering and Science Massachusetts Institute of Technology Cambridge MA 02139 USA

4. Department of Chemical Engineering University of Melbourne Parkville VIC 3010 Australia

5. Department of Chemistry Massachusetts Institute of Technology Cambridge MA 02139 USA

6. Global Health Labs 14360 SE Eastgate Way Bellevue WA 98007 USA

7. Department of Chemical Engineering Massachusetts Institute of Technology Cambridge MA 02139 USA

8. Department of Biological Engineering Massachusetts Institute of Technology Cambridge MA 02139 USA

9. Institute of Chemistry the Chinese Academy of Sciences (ICCAS) Beijing 100045 China

10. Department of Bioengineering Rice University Houston TX 77005 USA

11. Department of Chemistry Rice University Houston TX 77005 USA

Abstract

AbstractAccurate medical recordkeeping is important for personal and public health. Conventional forms of on‐patient medical information, such as medical alert bracelets or finger‐markings, may compromise patient privacy because they are readily visible to other people. Here, the development of an invisible, temporary, and easily deployable on‐patient medical recordkeeping system is reported. Information is stored in unique patterns of spatially distributed near‐infrared (NIR) fluorescent quantum dots (QDs), which are delivered to the skin using dissolvable microneedle arrays. The patterns are invisible to the naked eye but detectable with an infrared camera, which can extract information with >98% accuracy using automated pattern recognition software. By encapsulating NIR QDs in an FDA‐approved biodegradable polymer, biodegradation rates can be tuned so that the encoded medical information can be conveyed in both a spatial and temporal manner, with some components fading within 100 days and others persisting for 6 months. This may be particularly useful for administering a series of vaccinations or treatments by indicating if enough time has passed for the patient to receive the next dose. Importantly, this system contains no personal information, does not require connection to a centralized database, and is not visible to the naked eye, ensuring patient privacy.

Funder

Youth Innovation Promotion Association of the Chinese Academy of Sciences

National Natural Science Foundation of China

China Scholarship Council

National Science Foundation

Bill and Melinda Gates Foundation

Publisher

Wiley

Subject

Electrochemistry,Condensed Matter Physics,Biomaterials,Electronic, Optical and Magnetic Materials

Reference56 articles.

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4. USEPA Federal recordkeeping requirements under EPCRA §§311 and 312 https://www.epa.gov/epcra/federal‐recordkeeping‐requirements‐under‐epcra‐ssss311‐and‐312 2019.

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