Affiliation:
1. Key Laboratory of Dental Maxillofacial Reconstruction and Biological Intelligence Manufacturing Gansu Province School of Stomatology Lanzhou University Lanzhou 730000 P. R. China
Abstract
AbstractThe bioinertness, poor antibacterial properties, and weak osseointegration of polyether‐etherketone (PEEK) limit its clinical application as oral implants. In this study, it is developed a personalized and customizable PEEK implant with multifunctional capabilities through sequential 3D printing, surface sulfonation (SPEEK), and modification using a drug‐loaded photocured hydrogel composed of acrylic acid‐acrylamide (AA‐AM) containing simvastatin‐cefepime (SIM‐CFP). The modified implant, referred to as SCHSPEEK, mimics the structure of biomimetic periodontal ligament (PDL) fibers. The chemical composition, surface characteristics, and biological properties of SCHSPEEK both in vitro and in vivo are systematically investigated. The results demonstrate that hydrogel modification not only enhances hydrophilicity and reduces surface roughness and friction coefficient, but also improves biocompatibility, drug release, and antibacterial efficacy. Importantly, SCHSPEEK exhibits a significant improvement in osseointegration capacity in vivo. These findings highlight the potential of SCHSPEEK implants to serve as promising orthopedic and dental implants in clinical settings.
Funder
National Natural Science Foundation of China
Natural Science Foundation of Gansu Province
Fundamental Research Funds for the Central Universities
Chinese Academy of Sciences
Science and Technology Program of Gansu Province
Subject
Electrochemistry,Condensed Matter Physics,Biomaterials,Electronic, Optical and Magnetic Materials