Affiliation:
1. School of Chemistry & AMBER The SFI Research Centre for Advanced Materials and BioEngineering Research Trinity College Dublin Dublin 2 D02 PN40 Ireland
2. Department of Mechanical & Manufacturing Engineering Trinity College Dublin Dublin 2 D02 PN40 Ireland
3. Department of Surgery & Cancer Queen Elizabeth the Queen Mother Wing St Mary's Hospital Imperial College London South Wharf Road London W2 1NY UK
4. The Hamlyn Centre Institute of Global Health Innovation (IGHI) Imperial College London Exhibition Road, South Kensington London SW7 2AZ UK
Abstract
AbstractStimuli‐responsive hydrogels have attracted much attention owing to the versatility of their programmed response in offering intelligent solutions for biomimicry applications, such as soft robotics, tissue engineering, and drug delivery. To achieve the complexity of biomimetic structures, two photon polymerization (2PP) has provided a means of fabricating intricate 3D structures from stimuli‐responsive hydrogels. Rapid swelling hydrogel microstructures are advantageous for osmotically driven stimuli‐response, where actuation speed, that is reliant on the diffusion of analytes or bioanalytes, can be optimized. Herein, the flexibility of 2PP is exploited to showcase a novel sugar‐responsive, phenylboronic acid‐based photoresist. This offers a remarkable solution for achieving fast response hydrogel systems that have been often hindered by the volume‐dependent diffusion times of analytes to receptor sites. A phenylboronic acid‐based photoresist compatible with 2PP is presented to fabricate stimuli‐responsive microstructures with accelerated response times. Moreover, microstructures with programmable actuation (i.e., bending and opening) are fabricated using the same photoresist within a one‐step fabrication process. By combining the flexibility of 2PP with an easily adaptable photoresist, an accessible fabrication method is showcased for sophisticated and chemo‐responsive 3D hydrogel actuators.
Funder
European Research Council
Science Foundation Ireland
European Regional Development Fund
Irish Research Council
Subject
Electrochemistry,Condensed Matter Physics,Biomaterials,Electronic, Optical and Magnetic Materials
Cited by
9 articles.
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