Material–Structure–Function Integrated Additive Manufacturing of Degradable Metallic Bone Implants for Load‐Bearing Applications

Author:

Zhao Danlei1234,Yu Keda5,Sun Tingfang5,Jing Xirui5,Wan Yizhou5,Chen Kaifang5,Gao Hairui2,Wang Yifan3,Chen Lili134,Guo Xiaodong5,Wei Qingsong24ORCID

Affiliation:

1. Department of Stomatology Union Hospital Tongji Medical College Huazhong University of Science and Technology Wuhan 430022 P. R. China

2. State Key Lab of Materials Processing and Die & Mould Technology School of Materials Science and Engineering Huazhong University of Science and Technology Wuhan 430074 P. R. China

3. School of Stomatology Tongji Medical College Huazhong University of Science and Technology Wuhan 430030 P. R. China

4. Hubei Province Key Laboratory of Oral and Maxillofacial Development and Regeneration Wuhan 430022 P. R. China

5. Department of Orthopaedics Union Hospital Tongji Medical College Huazhong University of Science and Technology Wuhan 430022 P. R. China

Abstract

AbstractThe integration of bio‐adaptable performance, elaborate structure, and biological functionality for degradable bone implants is crucial in harnessing the body's regenerative potential to remold load‐bearing bone defects. Herein, material–structure–function integrated additive manufacturing (MSFI‐AM) is deployed to innovate novel zinc‐based bone implants, namely Zn–Mg–Cu alloy. In situ alloying of AM and boundary engineering strategy yield prominent mechanical properties, and the degradation products enable a mechanical self‐strengthened effect, thus coordinating mechanical degeneration and promoting mechanical adaptability. In addition, MSFI‐oriented Zn alloy implants successfully manifest in situ multifunctions of augmenting osteogenesis, immunoregulation, angiogenesis, and anti‐infective activity in vitro and expediting bone ingrowth and regeneration in vivo through the sustained release of divalent metal cations and triply periodic minimal surface (TPMS) structure construction. Overall, MSFI‐AMed Zn alloy implants signify promising clinical translation prospects for load‐bearing applications, and an integrated approach is proposed to endow degradable bone implants with boosted bio‐adaptable performance and in situ bio‐multifunctions.

Funder

National Natural Science Foundation of China

China Postdoctoral Science Foundation

Publisher

Wiley

Subject

Electrochemistry,Condensed Matter Physics,Biomaterials,Electronic, Optical and Magnetic Materials

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