Affiliation:
1. Department of Thoracic Surgery Shanghai Pulmonary Hospital School of Medicine Tongji University Shanghai 200433 China
2. Department of Infection Management Shanghai Pulmonary Hospital School of Medicine Tongji University Shanghai 200433 China
3. Multidisciplinary Centre for Advanced Materials Institute for Frontier Medical Technology School of Chemistry and Chemical Engineering Shanghai University of Engineering Science Shanghai 201620 China
4. Department of Anesthesiology Fudan University Shanghai Cancer Center Shanghai 200032 China
Abstract
AbstractPhotothermal therapy (PTT) is increasingly favored as a treatment option for lung cancer, a leading cause of cancer‐related death. However, the effectiveness of PTT is hampered by both tumor‐associated and treatment‐related inflammatory reactions. Consequently, there is a pressing need for innovative PTT‐based platforms capable of mitigating inflammation postcancer treatment. Herein, 2D vanadium carbide (V2C) MXenzyme nanosheets via a straightforward exfoliation and intercalation process are successfully synthesized. The V2C MXenzyme demonstrates a robust photothermal effect, which varied with concentration, density, and irradiation duration when exposed to 808 nm near‐infrared light. Notably, V2C MXenzyme exhibits the ability to eliminate A549 lung cancer cells both in vitro and in vivo through PTT. Additionally, the synthesized V2C MXenzyme nanosheets exhibited various enzyme‐like activities, resembling reactive oxygen species–mimetic enzymes, including superoxide dismutase, catalase, peroxidase, glutathione peroxidase, and thiol peroxidase. V2C MXenzyme significantly curtailed inflammation in both in vitro and in vivo settings. Furthermore, gene sequencing analysis of inflammation‐related genes responding to V2C MXenzyme nanosheets is performed and identified HSPA1A as a significantly differentially expressed gene. HSPA1A expression correlated with the infiltration of various immune cells in lung adenocarcinoma. Thus, V2C MXenzyme may serve as a revalorization platform to suppress lung tumors and reduce inflammation.
Funder
National Key Research and Development Program of China
National Natural Science Foundation of China
Program of Shanghai Academic Research Leader
Natural Science Foundation of Shanghai Municipality
Subject
Electrochemistry,Condensed Matter Physics,Biomaterials,Electronic, Optical and Magnetic Materials