Affiliation:
1. Teaching and Research Section of Nuclear Medicine School of clinical medicine & School of Basic Medical Sciences Anhui Medical University 81 Meishan Road Hefei 230032 P. R. China
2. School of clinical medicine Anhui Medical University 81 Meishan Road Hefei 230032 P. R. China
3. School of Biomedical Engineering Anhui Provincial Institute of Translational Medicine Anhui Medical University Hefei 230032 P. R. China
Abstract
AbstractBacteria have garnered significant attention in tumor immunotherapy recently years, owing to their immune‐activating properties, ease of genetic manipulation, and colonization abilities. In order to further enhance the safety, efficacy, and clinical translation potential of bacterial therapy, and to endow bacteria with additional functions, modifications or engineering of bacterial surfaces have emerged as a current research hotspot. This review systematically summarizes the primary methods and strategies for bacterial surface modification and engineering, including chemical alteration, physical modification, and bio‐modification. Subsequently, it is delve into the roles of these techniques in enhancing bacterial tumor immunotherapy, such as improving immunotherapeutic efficacy and reducing toxic side effects, and elucidate the underlying mechanisms. Finally, the current challenges faced in this field are deeply explored, and potential solutions for the future are presented. This work offers a comprehensive overview of the advancements in the new generation of bacterial surface modification techniques and their implications in bacterial‐based tumor immunotherapy.
Funder
National Natural Science Foundation of China
Natural Science Foundation of Anhui Province
Cited by
2 articles.
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