Long term therapeutic effects of icariin‐loaded PLGA microspheres in an experimental model of optic nerve ischemia via modulation of CEBP ‐β/ G‐CSF /noncanonical NF‐ κ B axis

Author:

Desai Tushar Dnyaneshwar1,Wen Yao‐Tseng1,Daddam Jayasimha Rayalu2,Cheng Felice3,Chen Chia‐Ching3,Pan Chien‐Lin3,Lin Keh‐Liang45,Tsai Rong‐Kung167ORCID

Affiliation:

1. Institute of Eye Research Hualien Tzu Chi Hospital, Buddhist Tzu Chi Medical Foundation Hualien Taiwan

2. Department of Animal Science Agriculture Research Organization, Volcani Center Rishon LeTsiyon Israel

3. Drug Delivery Technology Department Industrial Technology Research Institute Hsinchu Taiwan

4. Department of Medical Laboratory and Biotechnology Chung Shan Medical University Taichung Taiwan

5. Department of Medicine Mackay Medical College Taiwan

6. Institute of Medical Sciences Tzu Chi University Hualien Taiwan

7. Doctoral Degree Program in Translational Medicine Tzu Chi University and Academia Sinica Hualien Taiwan

Funder

Buddhist Tzu Chi Medical Foundation

Publisher

Wiley

Subject

Pharmaceutical Science,Biomedical Engineering,Biotechnology

Reference52 articles.

1. Nonarteritic anterior ischemic optic neuropathy: cause, effect, and management;Berry S;Eye Brain,2017

2. Optic nerve infarction and post‐ischemic inflammation in the rodent model of anterior ischemic optic neuropathy (rAION);Zhang C;Brain Res,2009

3. Cellular inflammation in nonarteritic anterior ischemic optic neuropathy and its primate model;Salgado C;Arch Ophthalmol,2011

4. Rodent anterior ischemic optic neuropathy (rAION) induces regional retinal ganglion cell apoptosis with a unique temporal pattern;Slater BJ;Invest Ophthalmol Vis Sci,2008

5. Early applications of granulocyte colony‐stimulating factor (G‐CSF) can stabilize the blood‐optic‐nerve barrier and ameliorate inflammation in a rat model of anterior ischemic optic neuropathy (rAION);Wen YT;Dis Model Mech,2016

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