Affiliation:
1. Department of Clinical Sciences Science and Research Branch Islamic Azad University Tehran Iran
2. Department of Physiology, Science and Research Branch Science and Research Branch Islamic Azad University Tehran Iran
3. Department of Epidemiology Faculty of Veterinary Medicine University of Tehran Tehran Iran
Abstract
AbstractBackgroundNo study has been performed regarding the effects of oral administration of propranolol on pulse‐wave spectral Doppler indices of major abdominal vessels in healthy adult cats.ObjectiveThe objective of this study was to assess the pulse‐wave spectral Doppler indices of abdominal aorta, caudal vena cava, and portal vein in clinically normal adult domestic short‐haired (DSH) cats, before and after propranolol ingestion.MethodsTwenty intact adult client‐owned DSH cats were evaluated (10 males and 10 females). A duplex Doppler ultrasonography machine with a 10‐MHz frequency linear transducer was used. Peak systolic velocity, end‐diastolic velocity (EDV), resistive index (RI), pulsatility index (PI), and pressure gradient were measured. All the cats received 1 mg/kg of propranolol tablet, and after 2 h, ultrasonography measurements were repeated.ResultsThe mean RI of the aorta and caudal vena cava significantly decreased in male cats following oral administration of propranolol after 2 h (p = 0.03, p = 0.02). In the caudal vena cava, the PI decreased from 2.98 ± 0.62 to 1.15 ± 0.19 post‐propranolol ingestion (p = 0.01). The mean EDV in the caudal vena cava of males and portal veins of females significantly decreased after propranolol ingestion (p = 0.04, p = 0.02).ConclusionsThis study showed that propranolol decreased the PI of the aorta and PI and RI of the caudal vena cava in healthy normal cats 2 h post‐propranolol ingestion at the dosage of 1 mg/kg.
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