Genome Engineering as a Therapeutic Approach in Cancer Therapy: A Comprehensive Review-Reference-Cited by-同舟云学术

Genome Engineering as a Therapeutic Approach in Cancer Therapy: A Comprehensive Review

Published:2024-02-05 Issue:1 Volume:5 Page:
ISSN:2641-6573
Container-title:Advanced Genetics
language:en
Short-container-title:Advanced Genetics

Author:

Gemayel Jack¹²,Chebly Alain³⁴,Kourie Hampig³⁵,Hanna Colette⁶,Mheidly Kayane⁷,Mhanna Melissa⁸,Karam Farah⁹,Ghoussaini Daniel⁹,Najjar Paula El²¹⁰,Khalil Charbel¹¹¹²¹³^ORCID

Affiliation:

1. Faculty of Sciences Balamand University Beirut Lebanon

2. FMPS Holding BIOTECKNO s.a.l. Research and Quality Solutions Naccash Beirut 60 247 Lebanon

3. Center Jacques Loiselet for Medical Genetics and Genomics (CGGM), Faculty of Medicine Saint Joseph University Beirut Lebanon

4. Higher Institute of Public Health Saint Joseph University Beirut Lebanon

5. Faculty of Medicine Saint Joseph University Beirut Lebanon

6. Faculty of Medicine Lebanese American University Medical Center Rizk Hospital Beirut Lebanon

7. Sheikh Shakhbout Medical City Abu Dhabi UAE

8. Faculty of Medicine Paris Saclay University 63 Rue Gabriel Péri Le Kremlin‐Bicêtre 94270 France

9. Faculty of Medicine Balamand University Beirut Lebanon

10. Department of Agricultural and Food Engineering, School of Engineering Holy Spirit University of Kaslik Jounieh 446 Lebanon

11. Reviva Regenerative Medicine Center Bsalim Lebanon

12. Bone Marrow Transplant Unit Burjeel Medical City Abu Dhabi UAE

13. Lebanese American University School of Medicine Beirut Lebanon

Abstract

AbstractCancer is one of the foremost causes of mortality. The human genome remains stable over time. However, human activities and environmental factors have the power to influence the prevalence of certain types of mutations. This goes to the excessive progress of xenobiotics and industrial development that is expanding the territory for cancers to develop. The mechanisms involved in immune responses against cancer are widely studied. Genome editing has changed the genome‐based immunotherapy process in the human body and has opened a new era for cancer treatment. In this review, recent cancer immunotherapies and the use of genome engineering technology are largely focused on.

Publisher

Wiley

Link

https://onlinelibrary.wiley.com/doi/pdf/10.1002/ggn2.202300201

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