The epidemiology of mild cognitive impairment, Alzheimer's disease and related dementia in U.S. veterans-Reference-Cited by-同舟云学术

The epidemiology of mild cognitive impairment, Alzheimer's disease and related dementia in U.S. veterans

Published:2023-04-28 Issue:9 Volume:19 Page:3977-3984
ISSN:1552-5260
Container-title:Alzheimer's & Dementia
language:en
Short-container-title:Alzheimer's & Dementia

Author:

Dinesh Deepika¹²,Shao Qing³,Palnati Madhuri³,McDannold Sarah³,Zhang Quanwu⁴,Monfared Amir Abbas Tahami⁴⁵,Jasuja Guneet K.³⁶,Davila Heather⁷⁸,Xia Weiming⁹¹⁰,Moo Lauren R.³⁹¹¹,Miller Donald R.²³,Palacios Natalia¹²⁹

Affiliation:

1. Department of Public Health University of Massachusetts at Lowell, Zuckerberg College of Health Sciences Lowell Massachusetts USA

2. Center for Population Health, Department of Biomedical and Nutritional Sciences University of Massachusetts Lowell Massachusetts USA

3. Bedford VA Healthcare System Center for Healthcare Organization and Implementation Research Bedford Massachusetts USA

4. Easai Inc. Neurology Business Group Woodcliff Lake New Jersey USA

5. McGill University Epidemiology, Biostatistics, and Occupational Health Montreal Quebec Canada

6. Section of General Internal Medicine Boston University School of Medicine Boston Massachusetts USA

7. Center for Access & Delivery Research and Evaluation Iowa City VA Healthcare System Iowa USA

8. General Internal Medicine University of Iowa Carver College of Medicine Iowa City Iowa USA

9. Bedford VA Healthcare System Geriatric Research and Education Clinical Center Bedford Massachusetts USA

10. Department of Pharmacology and Experimental Therapeutics Boston University School of Medicine Boston Massachusetts USA

11. Department of Neurology Harvard Medical School Boston Massachusetts USA

Abstract

AbstractIntroductionUS veterans have a unique dementia risk profile that may be evolving over time.MethodsAge‐standardized incidence and prevalence of Alzheimer's disease (AD), AD and related dementias (ADRD), and mild cognitive impairment (MCI) was estimated from electronic health records (EHR) data for all veterans aged 50 years and older receiving Veterans Health Administration (VHA) care from 2000 to 2019.ResultsThe annual prevalence and incidence of AD declined, as did ADRD incidence. ADRD prevalence increased from 1.07% in 2000 to 1.50% in 2019, primarily due to an increase in the prevalence of dementia not otherwise specified. The prevalence and incidence of MCI increased sharply, especially after 2010. The prevalence and incidence of AD, ADRD, and MCI were highest in the oldest veterans, in female veterans, and in African American and Hispanic veterans.DiscussionWe observed 20‐year trends of declining prevalence and incidence of AD, increasing prevalence of ADRD, and sharply increasing prevalence and incidence of MCI.

Publisher

Wiley

Subject

Psychiatry and Mental health,Cellular and Molecular Neuroscience,Geriatrics and Gerontology,Neurology (clinical),Developmental Neuroscience,Health Policy,Epidemiology

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