An environmental pollutant, 9,10-phenanthrenequinone, activates human TRPA1 via critical cysteines 621 and 665-Reference-Cited by-同舟云学术

An environmental pollutant, 9,10-phenanthrenequinone, activates human TRPA1 via critical cysteines 621 and 665

Published:2017-07-28 Issue:4 Volume:5 Page:e00342
ISSN:2052-1707
Container-title:Pharmacology Research & Perspectives
language:en
Short-container-title:Pharmacol Res Perspect

Author:

Muraki Katsuhiko¹^ORCID,Sekine Takashi¹²,Ando Yuna¹,Suzuki Hiroka¹,Hatano Noriyuki¹,Hirata Tadashi²,Muraki Yukiko¹

Affiliation:

1. Laboratory of Cellular Pharmacology; School of Pharmacy; Aichi-Gakuin University; 1-100 Kusumoto, Chikusa Nagoya 464-8650 Japan

2. R&D Group; Tobacco Business Headquarters; Scientific Product Assessment Center; Japan Tobacco Inc.; Yokohama 227-8512 Japan

Funder

Japan Society for the Promotion of Science

Publisher

Wiley

Subject

General Pharmacology, Toxicology and Pharmaceutics,Neurology

Reference46 articles.

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2. Cigarette smoke-induced neurogenic inflammation is mediated by alpha, beta-unsaturated aldehydes and the TRPA1 receptor in rodents;Andre;J Clin Invest,2008

3. Identification and quantification of in vivo metabolites of 9,10-phenanthrenequinone in human urine associated with producing reactive oxygen species;Asahi;Chem Res Toxicol,2014

4. Non-neuronal expression of transient receptor potential type A1 (TRPA1) in human skin;Atoyan;J Invest Dermatol,2009

5. The exceptionally high reactivity of Cys 621 is critical for electrophilic activation of the sensory nerve ion channel TRPA1;Bahia;J Gel Physiol,2016

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