Sex and gender differences in cognitive resilience to aging and Alzheimer's disease-Reference-Cited by-同舟云学术

Sex and gender differences in cognitive resilience to aging and Alzheimer's disease

Published:2024-07-05 Issue:8 Volume:20 Page:5695-5719
ISSN:1552-5260
Container-title:Alzheimer's & Dementia
language:en
Short-container-title:Alzheimer's & Dementia

Author:

Arenaza‐Urquijo Eider M.¹²,Boyle Rory³,Casaletto Kaitlin⁴,Anstey Kaarin J.⁵⁶⁷,Vila‐Castelar Clara³,Colverson Aaron⁸,Palpatzis Eleni¹²,Eissman Jaclyn M.⁹¹⁰,Kheng Siang Ng Ted¹¹,Raghavan Sheelakumari¹²,Akinci Muge¹²,Vonk Jet M. J.⁴,Machado Luiza S.¹³,Zanwar Preeti P.¹⁴¹⁵,Shrestha Hom L.¹⁶,Wagner Maude¹⁷,Tamburin Stefano¹⁸,Sohrabi Hamid R.¹⁹²⁰,Loi Samantha²¹²²,Bartrés‐Faz David²³²⁴²⁵,Dubal Dena B.²⁶²⁷,Vemuri Prashanthi¹²,Okonkwo Ozioma²⁸,Hohman Timothy J.⁹¹⁰,Ewers Michael²⁹³⁰,Buckley Rachel F.³,

Affiliation:

1. Environment and Health Over the Life Course Programme, Climate, Air Pollution, Nature and Urban Health Programme Barcelona Institute for Global Health (ISGlobal) Barcelona Spain

2. University of Pompeu Fabra Barcelona Barcelona Spain

3. Massachusetts General Hospital Harvard Medical School Boston Massachusetts USA

4. Department of Neurology Memory and Aging Center University of California San Francisco San Francisco California USA

5. University of New South Wales Ageing Futures Institute Sydney New South Wales Australia

6. Neuroscience Research Australia Sydney New South Wales Australia

7. School of Psychology, University of New South Wales Sidney New South Wales Australia

8. University of Florida Center for Arts in Medicine Interdisciplinary Research Lab University of Florida, Center of Arts in Medicine Gainesville Florida USA

9. Vanderbilt Memory and Alzheimer's Center, Department of Neurology Vanderbilt University Medical Center Nashville Tennessee USA

10. Vanderbilt Genetics Institute Vanderbilt University Medical Center Nashville Tennessee USA

11. Rush Institute for Healthy Aging and Department of Internal Medicine Rush University Medical Center Chicago Illinois USA

12. Department of Radiology Mayo Clinic Rochester Minnesota USA

13. Graduate Program in Biological Sciences: Biochemistry, Universidade Federal Do Rio Grande Do Sul, Farroupilha Porto Alegre Brazil

14. Jefferson College of Population Health, Thomas Jefferson University Philadelphia Pennsylvania USA

15. The Network on Life Course and Health Dynamics and Disparities, University of Southern California Los Angeles California USA

16. Laurentian University Sudbury Ontario Canada

17. Rush Alzheimer's Disease Center, Rush University Medical Center Chicago Illinois USA

18. Department of Neurosciences, Biomedicine and Movement Sciences University of Verona Verona Italy

19. Centre for Healthy Ageing Health Future Institute Murdoch University Murdoch Western Australia Australia

20. School of Psychology, Murdoch University Murdoch Western Australia Australia

21. Neuropsychiatry Centre, Royal Melbourne Hospital Parkville Victoria Australia

22. Department of Psychiatry University of Melbourne Parkville Victoria Australia

23. Department of Medicine Faculty of Medicine and Health Sciences & Institut de Neurociències University of Barcelona Barcelona Barcelona Spain

24. Institut d'Investigacions Biomèdiques (IDIBAPS) Barcelona Barcelona Spain

25. Institut Guttmann, Institut Universitari de Neurorehabilitació adscrit a la Universitat Autónoma de Barcelona Badalona Barcelona Spain

26. Department of Neurology and Weill Institute of Neurosciences University of California, San Francisco San Francisco California USA

27. Biomedical and Neurosciences Graduate Programs University of California, San Francisco San Francisco California USA

28. Alzheimer's Disease Research Center and Department of Medicine University of Wisconsin School of Medicine and Public Health Madison Wisconsin USA

29. Institute for Stroke and Dementia Research Klinikum der Universität München Ludwig Maximilians Universität (LMU) Munich Germany

30. German Center for Neurodegenerative Diseases (DZNE, Munich) Munich Germany

Abstract

AbstractSex and gender—biological and social constructs—significantly impact the prevalence of protective and risk factors, influencing the burden of Alzheimer's disease (AD; amyloid beta and tau) and other pathologies (e.g., cerebrovascular disease) which ultimately shape cognitive trajectories. Understanding the interplay of these factors is central to understanding resilience and resistance mechanisms explaining maintained cognitive function and reduced pathology accumulation in aging and AD. In this narrative review, the ADDRESS! Special Interest Group (Alzheimer's Association) adopted a multidisciplinary approach to provide the foundations and recommendations for future research into sex‐ and gender‐specific drivers of resilience, including a sex/gender‐oriented review of risk factors, genetics, AD and non‐AD pathologies, brain structure and function, and animal research. We urge the field to adopt a sex/gender‐aware approach to resilience to advance our understanding of the intricate interplay of biological and social determinants and consider sex/gender‐specific resilience throughout disease stages.Highlights

Sex differences in resilience to cognitive decline vary by age and cognitive status.

Initial evidence supports sex‐specific distinctions in brain pathology.

Findings suggest sex differences in the impact of pathology on cognition.

There is a sex‐specific change in resilience in the transition to clinical stages.

Gender and sex factors warrant study: modifiable, immune, inflammatory, and vascular.

Funder

Ministerio de Ciencia e Innovación

Alzheimer's Association

National Institute on Aging

Simons Foundation

Publisher

Wiley