Growth and maturation of primary-cultured adipocytes from lean and ob/ob mice
Author:
Publisher
Wiley
Subject
Cell Biology,Molecular Biology,Biochemistry
Reference32 articles.
1. Coupling growth arrest and adipocyte differentiation.
2. Absence of the inhibitory effect of guanine nucleotides on adenylate cyclase activity in white adipocyte membranes of the ob/ob mouse. Effect of the ob gene.
3. Quantification of the α and β subunits of the transducing elements (Gs and Gi) of adenylate cyclase in adipocyte membranes from lean and obese (ob/ob) mice
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1. Depot- and obesity-related differences in adipogenesisAdipocyte hypertrophy and hyperplasia are known to facilitate lipid storage in adipose tissues by increasing adipocyte cell size and number, respectively. Adipogenesis is the process resulting in adipose tissue hyperplasia. Although depot-specific differences and obesity-related modulation of adipocyte size are well documented, available data on adipogenesis and adipose tissue hyperplasia are less conclusive. Most studies support a reduction of adipogenesis in the obese state. Preadipocytes of the subcutaneous fat depot appear to be more responsive to adipogenic stimulation compared with those from visceral fat compartments in most studies. A number of studies support the notion that adipose tissue expansion through hyperplasia reduces ectopic lipid excess and obesity-related complications. Several genetic variants have been identified in the genes coding for adipogenesis-regulating proteins. While some of these variants have been clearly associated with the phenotypes of obesity and obesity-related alterations, available data highlight the importance of considering gene–gene and gene–diet interactions.;Clinical Lipidology;2012-10-01
2. Cadmium inhibits the differentiation of 3T3-L1 preadipocyte through the C/EBPα and PPARγ pathways;Drug and Chemical Toxicology;2011-08-18
3. Islet-1: A Potentially Important Role for an Islet Cell Gene in Visceral Fat;Obesity;2008-02
4. Reduced Adiposity in ob/ob Mice following Total Body Irradiation and Bone Marrow Transplantation*;Obesity;2007-06
5. Maternal protein restriction permanently programs adipocyte growth and development in adult male rat offspring;Journal of Cellular Biochemistry;2007
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