Tanshinone IIA combined with cisplatin synergistically inhibits non‐small‐cell lung cancer in vitro and in vivo via down‐regulating the phosphatidylinositol 3‐kinase/Akt signalling pathway

Author:

Liao Xiao‐Zhong12,Gao Ying2,Huang Sheng3,Chen Zhuang‐Zhong1,Sun Ling‐Ling1,Liu Jia‐Hui2,Chen Han‐Rui1,Yu Ling1,Zhang Jia‐Xing2,Lin Li‐Zhu1ORCID

Affiliation:

1. Department of OncologyThe First Affiliated Hospital of Guangzhou University of Chinese Medicine Guangzhou China

2. Department of OncologyThe First Affiliated Hospital, Sun Yat‐sen University Guangzhou China

3. Department of Orthopaedic SurgeryThe First Affiliated Hospital of Nanchang University Nanchang China

Funder

Natural Science Foundation of Guangdong Province

National Natural Science Foundation of China

Publisher

Wiley

Subject

Pharmacology

Reference35 articles.

1. The anticancer mechanism investigation of Tanshinone IIA by pharmacological clustering in protein network

2. Tripchlorolide induces autophagy in lung cancer cells by inhibiting the PI3K/AKT/mTOR pathway and improves cisplatin sensitivity in A549/DDP cells

3. Drug-target networks for Tanshinone IIA identified by data mining

4. Anti‐inflammatory and immunomodulatory mechanism of Tanshinone IIA for atherosclerosis;Chen Z.;Evidence‐based Complementary and Alternative Medicine: Ecam,2014

5. Tanshinone IIA induces apoptosis in human lung cancer A549 cells through the induction of reactive oxygen species and decreasing the mitochondrial membrane potential;Chiu T. L.;International Journal of Molecular Medicine,2010

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