The Raf‐1 Protein Mediates Insulin‐Like Growth Factor‐Induced Proliferation of Erythroid Progenitor Cells

Author:

Sanders Marilyn R.1,Lu Hsienwie1,Walker Frederick12,Sorba Sandra3,Dainiak Nicholas3

Affiliation:

1. Departments of Pediatrics and Laboratory Medicine, University of Connecticut School of Medicine, Connecticut, USA

2. The American Red Cross, Farmington, Connecticut, USA

3. Department of Medicine, The Bridgeport Hospital, Yale University School of Medicine, Bridgeport, Connecticut, USA

Publisher

Oxford University Press (OUP)

Subject

Cell Biology,Developmental Biology,Molecular Medicine

Reference33 articles.

1. Insulin activates the Raf‐1 protein kinase.;Blackshear PJ;J Biol Chem,1990

2. Insulin activates the kinase activity of the Raf‐1 proto‐oncogene by increasing its serine phosphorylation.;Kovacina KS;J Biol Chem,1990

3. Direct activation of the serine/threonine kinase activity of raf-1 through tyrosine phosphorylation by the PDGF β-receptor

4. Epidermal growth factor (EGF) stimulates association and kinase activity of Raf-1 with the EGF receptor.

5. Comparative analysis of signaling pathways between mast cell growth factor (c‐kit ligand) and granulocyte‐macrophage colony‐stimulating factor in a human factor‐dependent myeloid cell line involves phosphorylation of Raf‐1, GTPase‐activating protein and mitogen‐activated kinase.;Miyazawa K;Exp Hematol,1991

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