Probabilistic Design space determination in pharmaceutical product development: A Bayesian/latent variable approach

Author:

Bano Gabriele1,Facco Pierantonio1,Bezzo Fabrizio1ORCID,Barolo Massimiliano1ORCID

Affiliation:

1. CAPE‐Lab—Computer‐Aided Process Engineering Laboratory, Dept. of Industrial EngineeringUniversity of Padova35131 Padova PD Italy

Funder

University of Padova

Publisher

Wiley

Subject

General Chemical Engineering,Environmental Engineering,Biotechnology

Reference31 articles.

1. ICH. ICH Harmonised Tripartite Guideline Guidance for Industry Pharmaceutical Development Q8(R2). International Conference on Harmonisation of Technical Requirements for Registration of Pharmaceuticals for Human Use. Silver Spring MD: ICH 2009.

2. Propagation of measurement errors for the validation of predictions obtained by principal component regression and partial least squares

3. Integration of data uncertainty in linear regression and process optimization

4. A Bayesian Approach to the ICH Q8 Definition of Design Space

5. Find the most favorable formulations;Anderson MJ;Chem Eng Progr.,1998

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