Sleep disturbances are key symptoms of very early stage Alzheimer disease with behavioral and psychological symptoms: a Japan multi-center cross-sectional study (J-BIRD)

Author:

Kabeshita Yasunobu123,Adachi Hiroyoshi123,Matsushita Masateru45,Kanemoto Hideki2,Sato Shunsuke2,Suzuki Yukiko2,Yoshiyama Kenji2,Shimomura Tatsuo6,Yoshida Taku7,Shimizu Hideaki7,Matsumoto Teruhisa7,Mori Takaaki7,Kashibayashi Tetsuo8,Tanaka Hibiki4,Hatada Yutaka4,Hashimoto Mamoru4,Nishio Yoshiyuki9,Komori Kenjiro710,Tanaka Toshihisa2,Yokoyama Kazumasa8,Tanimukai Satoshi11,Ikeda Manabu4,Takeda Masatoshi112,Mori Etsuro9,Kudo Takashi12,Kazui Hiroaki2

Affiliation:

1. Department of Psychiatry; Osaka University Health Care Center; Toyonaka Japan

2. Psychiatry, Department of Integrated Medicine, Division of Internal Medicine; Osaka University Graduate School of Medicine; Suita Japan

3. The Sleep Medical Center of Osaka University Hospital; Suita Japan

4. Department of Neuropsychiatry, Faculty of Life Sciences; Kumamoto University; Kumamoto Japan

5. Center for Medical Education and Research, Faculty of Life Sciences; Kumamoto University; Kumamoto Japan

6. Department of Rehabilitation Medicine; Akita Prefectural Centre of Rehabilitation and Psychiatric Medicine; Daisen Japan

7. Department of Neuropsychiatry, Graduate School of Medicine; Ehime University; Toon Japan

8. Departments of Neurology and Cognitive Disorders; Hyogo Prefectural Rehabilitation Center at Nishi-harima; Tatsuno Japan

9. Department of Behavioral Neurology and Cognitive Neuroscience; Tohoku University Graduate School of Medicine; Sendai Japan

10. Zaidan-Niihama Hospital; Niihama Japan

11. Department of Community and Geriatric Nursing; Ehime University Graduate School of Medicine; Toon Japan

12. Aino University; Ibaraki Japan

Funder

Ministry of Health, Labor, and Welfare of Japan

Publisher

Wiley

Subject

Psychiatry and Mental health,Geriatrics and Gerontology

Reference39 articles.

1. Variations in circadian rhythms of activity, sleep, and light exposure related to dementia in nursing-home patients;Ancoli-Israel;Sleep,1997

2. Incidence and predictive factors of depressive symptoms in Alzheimer's disease: the REAL.FR study;Arbus;J Nutr Health Aging,2011

3. Controlling the false discovery rate: a practical and powerful approach to multiple testing;Benjamini;J Royal Stat Soc B, Stat Methodol,1995

4. Observed sleep/wakefulness and severity of dementia in an Alzheimer's disease special care unit;Bliwise;J Gerontol A Biol Sci Med Sci,1995

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