Affiliation:
1. Department of Pathology Fudan University Shanghai Cancer Center Shanghai China
2. Department of Oncology Shanghai Medical College, Fudan University Shanghai China
3. Institute of Pathology Fudan University Shanghai China
4. Department of Pathology The First Affiliated Hospital of Zhejiang University Hangzhou China
5. Department of Pathology Affiliated Cancer Hospital of Zhengzhou University Zhengzhou China
6. Department of Medical Oncology Fudan University Shanghai Cancer Center Shanghai China
Abstract
AbstractPurposeLarge B‐cell lymphoma with IRF4 rearrangement (LBCL, IRF4+) has been recently recognized as a specific entity that is frequently associated with young age and favorable prognosis. However, whether the good outcome of the disease is due to IRF4+ or other factors remains obscure. We thus analyzed 100 young patients with primary head and neck LBCL to see the clinicopathologic correlates of IRF4+.MethodsThe histopathology, immunophenotype, IRF4 status of the tumors, and clinical data were reviewed.ResultsTwenty‐one tumors were diagnosed as LBCL, IRF4+, which were more frequently associated with a follicular growth pattern, medium‐sized blastoid cytology, germinal center B‐cell‐like, and CD5+ phenotype, compared with IRF4− ones. While most of the patients received chemotherapy with or without radiation, eight IRF4+ patients received mere surgical resection of the tumor and exhibited excellent outcome. IRF4+ cases featured a significantly higher complete remission rate, and better survivals compared with IRF4− ones. Multivariate analysis confirmed IRF4+ correlates with a better survival.ConclusionOur work confirmed the unique clinicopathologic features of LBCL, IRF4+, and disclosed for the first time the independent favorable prognostic impact of IRF4+. These findings may further unravel the heterogeneity of LBCL occurring in youth, and aid in risk stratification and tailoring the therapeutic strategy.
Funder
Chinese Society of Clinical Oncology
Science and Technology Commission of Shanghai Municipality
Subject
Cancer Research,Radiology, Nuclear Medicine and imaging,Oncology
Cited by
1 articles.
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