Impact of gavage dosing procedure and gastric content on adverse respiratory effects and mortality in rat toxicity studies

Author:

Eichenbaum G.,Damsch S.,Looszova A.,Vandenberghe J.,Van den Bulck K.,Roels K.,Megens A.,Knight E.,Hillsamer V.,Feyen B.,Kelley M. F.,Tonelli A.,Lammens L.

Publisher

Wiley

Subject

Toxicology

Reference11 articles.

1. Interactive effect of morphine and dexmedetomidine on gastric emptying and gastrointestinal transit in the rat;Asai;Br. J. Anaesth.,1998

2. Improved oral dosing technique for rats;Conybeare;J. Pharmacol. Meth.,1988

3. Gavage-related reflux in Rats: indentification, pathogenesis and teoxicological implications;Damsch;Toxicol Pathol,2011a

4. Unexpected nasal changes in rats related to reflux after gavage dosing;Damsch;Toxicol Pathol,2011b

5. De Jonghe S Lammens L Raoof A Steemans K Broeckaert F Verbeeck J Van Goethem F Hanton , G. 2009 Lethal rhinitis/sinusitis in rodents by aspiration of formulation in gavage studies: importance of evaluation of the nose 6th European Congress of Toxicologic Pathology

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