Cucumeropsis mannii seed oil (CMSO) restores testicular mitochondrial dysfunctions by modulating the activities of dysregulated testicular mitochondrial enzymes in male albino rats exposed to bisphenol A

Author:

Ogwoni H. A.12,Aja P. M.13ORCID,Eze Ejike Daniel4,Agu P. C.1,Moyosore Afodun Adam5,Ale B. A.6ORCID,Ekpono E. U.7,Awoke J. N.1,Ogbu Patience N.8,Ukachi O. U.1,Orji O. U.1,Nweke P. C.1,Egwu C. O.8,Ekpono E. U.1,Ewa G. O.1,Igwenyi I. O.1,Alum E. U.1,Chukwu D. C.1,Aja Lucy9,Ani G. O.1,Offor C. E.1,Yakubu O. E.10,Maduagwuna E.1,Akobi J. B.2,Noreen Sana11,Awuchi Chinaza Godswill312ORCID

Affiliation:

1. Department of Biochemistry, Faculty of Science Ebonyi State University Abakaliki Nigeria

2. Department of Medical Biochemistry, Faculty of Basic Medical Sciences Cross River University of Technology (CRUTECH) Calabar Nigeria

3. Department of Biochemistry, Faculty of Biomedical Sciences Kampala International University Bushenyi Uganda

4. Department of Physiology, School of Medicine Kabale University Kabale Uganda

5. Department of Anatomy and Cell Biology, Faculty of Health Sciences Busitema University Sukulu Uganda

6. Department of Biochemistry, Faculty of Biological Sciences University of Nigeria Nsukka Nigeria

7. Department of Science Laboratory Technology, Biochemistry Option Federal Polytechnic Oko Nigeria

8. Department of Medical Biochemistry, Faculty of Basic Medical Sciences, College of Medicine Alex‐Ekwueme Federal University, Ndufu‐Alike Ikwo Nigeria

9. Department of Science Education, Faculty of Education Ebonyi State University Abakaliki Nigeria

10. Department of Biochemistry, Faculty of Sciences Federal University Wukari Nigeria

11. University Institute of Diet and Nutritional Sciences University of Lahore Lahore Pakistan

12. School of Natural and Applied Sciences Kampala International University Kampala Uganda

Abstract

AbstractBisphenol A, a traditional endocrine disruptor, has been implicated in male infertility. This study investigated the effect of Cucumeropsis mannii seed oil (CMSO) on bisphenol A (BPA)‐induced biochemical toxicity in the testicular mitochondria of male albino rats. The rats were assigned randomly to six experimental groups (n = 6), A, B, C, D, E, and F. Group A received 1 mL of olive oil. Groups B and C received 100 mL/kg body weight (BW) of BPA and 7.5 mL/kg BW CMSO, respectively. Rats in groups D, E, and F received preadministered doses of 100 mL/kg BW of BPA, 5 mL/kg BW of BPA, and 2.5 mL/kg BW of CMSO, respectively, followed by 6 weeks of exposure to those doses. Some mitochondrial enzymes, mitochondrial membrane potential (MMP), mitochondria testicular protein, and body weight of rats were determined using standard methods. BPA significantly reduced succinate dehydrogenase, malate dehydrogenase, isocitrate dehydrogenase, NADH dehydrogenase, and monoamine oxidase activity. Also, BPA prominently decreased the MMP, mitochondrial testicular protein, and body weight of rats. Interestingly, coadministration of BPA and CMSO restored the dysregulated activities of the enzymes and levels of other biomarkers. We postulated that CMSO may be a promising drug for treating systemic toxicity caused by environmental toxicants such as BPA.

Publisher

Wiley

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