Affiliation:
1. Danish Dementia Research Centre Department of Neurology Copenhagen University Hospital ‐ Rigshospitalet Copenhagen Denmark
2. Department of Clinical Medicine University of Copenhagen Copenhagen Denmark
3. Department of Affective Disorders Aarhus University Hospital Psychiatry Aarhus Denmark
4. Department of Clinical Medicine Aarhus University Aarhus Denmark
5. National Centre for Register‐Based Research Aarhus University Aarhus Denmark
6. Centre for Integrated Register‐based Research Aarhus University Aarhus Denmark
Abstract
AbstractINTRODUCTIONProton pump inhibitors (PPIs) may increase dementia risk. However, it is currently unknown whether timing of exposure or age at dementia diagnosis influence the risk.METHODSWe assessed associations between cumulative PPI use and dementia at different ages in a nationwide Danish cohort of 1,983,785 individuals aged 60 to 75 years between 2000 and 2018.RESULTSDuring follow‐up, there were 99,384 all‐cause dementia incidences. Incidence rate ratio (IRR) of dementia with PPI ever‐use compared with never‐use was 1.36 (95% CI, 1.29 to 1.43) for age 60 to 69 years at diagnosis, 1.12 (1.09 to 1.15) for 70 to 79 years, 1.06 (1.03 to 1.09) for 80 to 89 years, and 1.03 (0.91 to 1.17) for 90+ years. Longer treatment duration yielded increasing IRRs. For cases below 90 years, increased dementia rate was observed regardless of treatment initiation up to >15 years before diagnosis.DISCUSSIONRegardless of timing of treatment initiation, PPI use was associated with increased dementia rate before age 90 years. Dementia rates increased with younger age at diagnosis.HIGHLIGHTS
After following 1,983,785 individuals for a median of 10 years, 99,384 developed dementia
PPIs were used by 21.2% of cases and 18.9% of controls
PPI use was associated with increased dementia rate regardless of time of treatment onset
Magnitude of associations increased with younger age at diagnosis
PPI use was not associated with dementia occurring after age 90 years
Subject
Psychiatry and Mental health,Cellular and Molecular Neuroscience,Geriatrics and Gerontology,Neurology (clinical),Developmental Neuroscience,Health Policy,Epidemiology
Cited by
9 articles.
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