Cerebrospinal fluid biomarkers in the Longitudinal Early‐onset Alzheimer's Disease Study-Reference-Cited by-全球学者库

Cerebrospinal fluid biomarkers in the Longitudinal Early‐onset Alzheimer's Disease Study

Published:2023-07-25 Issue:S9 Volume:19 Page:
ISSN:1552-5260
Container-title:Alzheimer's & Dementia
language:en
Short-container-title:Alzheimer's & Dementia

Author:

Dage Jeffrey L.¹²,Eloyan Ani³,Thangarajah Maryanne³,Hammers Dustin B.¹,Fagan Anne M.⁴,Gray Julia D.⁴,Schindler Suzanne E.⁴,Snoddy Casey²,Nudelman Kelly N. H.²,Faber Kelley M.²,Foroud Tatiana²,Aisen Paul⁵,Griffin Percy⁶,Grinberg Lea T.⁷⁸,Iaccarino Leonardo⁷,Kirby Kala¹,Kramer Joel⁷,Koeppe Robert⁹,Kukull Walter A.¹⁰,La Joie Renaud⁷,Mundada Nidhi S⁷,Murray Melissa E.¹¹,Rumbaugh Malia²,Soleimani‐Meigooni David N.⁷,Toga Arthur W.¹²,Touroutoglou Alexandra¹³,Vemuri Prashanthi¹⁴,Atri Alireza¹⁵,Beckett Laurel A.¹⁶,Day Gregory S.¹⁷,Graff‐Radford Neill R.¹⁷,Duara Ranjan¹⁸,Honig Lawrence S.¹⁹,Jones David T.¹⁴²⁰,Masdeu Joseph C.²¹,Mendez Mario F.²²,Musiek Erik⁴,Onyike Chiadi U.²³,Riddle Meghan²⁴,Rogalski Emily²⁵,Salloway Stephen²⁴,Sha Sharon J.²⁶,Turner Raymond S.²⁷,Wingo Thomas S.²⁸,Wolk David A.²⁹,Womack Kyle B.⁴,Carrillo Maria C.⁶,Dickerson Bradford C.¹³,Rabinovici Gil D.⁷,Apostolova Liana G.¹⁵³⁰,

Affiliation:

1. Department of Neurology Indiana University School of Medicine Indianapolis Indiana USA

2. Department of Medical and Molecular Genetics Indiana University School of Medicine Indianapolis Indiana USA

3. Department of Biostatistics Center for Statistical Sciences Brown University Providence Rhode Island USA

4. Department of Neurology Washington University in St. Louis St. Louis Missouri USA

5. Alzheimer's Therapeutic Research Institute University of Southern California San Diego California USA

6. Medical & Scientific Relations Division Alzheimer's Association Chicago Illinois USA

7. Department of Neurology University of California – San Francisco San Francisco California USA

8. Department of Pathology University of California – San Francisco San Francisco California USA

9. Department of Radiology University of Michigan Ann Arbor Michigan USA

10. Department of Epidemiology University of Washington Seattle Washington USA

11. Department of Neuroscience Mayo Clinic Jacksonville Florida USA

12. Laboratory of Neuro Imaging USC Stevens Neuroimaging and Informatics Institute Keck School of Medicine of USC Los Angeles California USA

13. Department of Neurology Massachusetts General Hospital and Harvard Medical School Boston Massachusetts USA

14. Department of Radiology Mayo Clinic Rochester Minnesota USA

15. Banner Sun Health Research Institute Sun City Arizona USA

16. Department of Public Health Sciences University of California‐Davis Davis California USA

17. Department of Neurology Mayo Clinic Jacksonville Florida USA

18. Wien Center for Alzheimer's Disease and Memory Disorders Mount Sinai Medical Center Miami Florida USA

19. Taub Institute and Department of Neurology Columbia University Irving Medical Center New York New York USA

20. Department of Neurology Mayo Clinic Rochester Minnesota USA

21. Nantz National Alzheimer Center Houston Methodist and Weill Cornell Medicine Houston Texas USA

22. Department of Neurology David Geffen School of Medicine at UCLA Los Angeles California USA

23. Department of Psychiatry and Behavioral Sciences Johns Hopkins University School of Medicine Baltimore Maryland USA

24. Department of Neurology Alpert Medical School Brown University Providence Rhode Island USA

25. Department of Psychiatry and Behavioral Sciences Mesulam Center for Cognitive Neurology and Alzheimer's Disease Feinberg School of Medicine Northwestern University Chicago Illinois USA

26. Department of Neurology & Neurological Sciences Stanford University Palo Alto California USA

27. Department of Neurology Georgetown University Washington D.C. USA

28. Department of Neurology and Human Genetics Emory University School of Medicine Atlanta Georgia USA

29. Department of Neurology Perelman School of Medicine University of Pennsylvania Philadelphia Pennsylvania USA

30. Department of Radiology and Imaging Sciences Center for Neuroimaging Indiana University School of Medicine Indianapolis Indianapolis Indiana USA

Abstract

AbstractIntroductionOne goal of the Longitudinal Early Onset Alzheimer's Disease Study (LEADS) is to define the fluid biomarker characteristics of early‐onset Alzheimer's disease (EOAD).MethodsCerebrospinal fluid (CSF) concentrations of Aβ1‐40, Aβ1‐42, total tau (tTau), pTau181, VILIP‐1, SNAP‐25, neurogranin (Ng), neurofilament light chain (NfL), and YKL‐40 were measured by immunoassay in 165 LEADS participants. The associations of biomarker concentrations with diagnostic group and standard cognitive tests were evaluated.ResultsBiomarkers were correlated with one another. Levels of CSF Aβ42/40, pTau181, tTau, SNAP‐25, and Ng in EOAD differed significantly from cognitively normal and early‐onset non‐AD dementia; NfL, YKL‐40, and VILIP‐1 did not. Across groups, all biomarkers except SNAP‐25 were correlated with cognition. Within the EOAD group, Aβ42/40, NfL, Ng, and SNAP‐25 were correlated with at least one cognitive measure.DiscussionThis study provides a comprehensive analysis of CSF biomarkers in sporadic EOAD that can inform EOAD clinical trial design.

Publisher

Wiley

Subject

Psychiatry and Mental health,Cellular and Molecular Neuroscience,Geriatrics and Gerontology,Neurology (clinical),Developmental Neuroscience,Health Policy,Epidemiology

Reference31 articles.

1. Global, regional, and national burden of Alzheimer's disease and other dementias, 1990–2019

2. The prevalence and causes of dementia in people under the age of 65 years

3. 2022 Alzheimer's disease facts and figures

4. Excessive tau accumulation in the parieto-occipital cortex characterizes early-onset Alzheimer's disease