Association between nighttime urinary frequency and clinical outcomes in Japanese patients with ulcerative colitis

Author:

Kitahata Shogo1ORCID,Furukawa Shinya2ORCID,Miyake Teruki3ORCID,Yoshida Osamu3ORCID,Shiraishi Kana3ORCID,Hashimoto Yu3ORCID,Tange Kazuhiro4ORCID,Sen Yagi5ORCID,Hanayama Masakazu6ORCID,Ninomiya Tomoyuki1ORCID,Suzuki Seiyuu7,Shibata Naozumi8,Murakami Hidehiro9,Ohashi Katsuhisa10ORCID,Tomida Hideomi11ORCID,Yamamoto Yasunori11ORCID,Takeshita Eiji4ORCID,Ikeda Yoshio11ORCID,Hiasa Yoichi3ORCID

Affiliation:

1. Department of Gastroenterology Ehime Prefectural Central Hospital Matsuyama Ehime Japan

2. Health Services Center, Ehime University Matsuyama Ehime Japan

3. Department of Gastroenterology and Metabology Ehime University Graduate School of Medicine Toon Ehime Japan

4. Department of Inflammatory Bowel Diseases and Therapeutics Ehime University Graduate School of Medicine, Shitsukawa Toon Ehime Japan

5. Department of Internal Medicine Saiseikai Imabari Hospital Imabari Ehime Japan

6. Department of Gastroenterology Matsuyama Shimin Hospital Matsuyama Ehime Japan

7. Department of Gastroenterology Sumitomo Besshi Hospital Niihama Japan

8. Department of Gastroenterology Ehime Prefectural Niihama Hospital Niihama Ehime Japan

9. Department of Internal Medicine Saiseikai Matsuyama Hospital Matsuyama Ehime Japan

10. OHASHI Clinic Participate in Gastro‐Enterology and Ano‐Proctology Niihama Ehime Japan

11. Endoscopy Center, Ehime University Hospital Toon Ehime Japan

Abstract

AbstractIntroductionNocturia is a common symptom of lower urinary tract syndrome (LUTS). In previous studies, a close association between LUTS and colorectal inflammation has been reported. However, evidence regarding the association between nighttime urinary frequency and ulcerative colitis (UC) is limited. Herein, we investigated the association between nighttime urinary frequency and clinical outcomes of UC.MethodsWe surveyed 287 Japanese patients with UC. A self‐administered questionnaire was used to collect the information on the variables studied. Patients were divided into three groups based on nighttime urinary frequency: (1) no voids, (2) one void, and (3) two or more voids. The assessment of clinical outcomes was based on mucosal healing (MH) and clinical remission (CR). The association between nighttime urinary frequency and prevalence of MH and CR was evaluated using multivariate logistic regression analyses.ResultsThe prevalence of one nighttime frequency and two or more nighttime frequency in this cohort was 35.5% and 26.8%, respectively. The percentage of MH and CR was 24.7% and 59.2%, respectively. Two or more nighttime frequency (adjusted odds ratio [OR]: 0.31, 95% confidence interval [CI]: 0.13–0.73) was independently and inversely associated with MH. In nonelderly patients (<70 years) and patients in CR, an association between two or more nighttime frequency and MH remained significant (non‐elderly: adjusted OR: 0.27, 95% CI: 0.09–0.72 and only CR: adjusted OR: 0.34, 95% CI: 0.12–0.90).ConclusionNighttime urinary frequency was independently and inversely associated with MH in Japanese patients with UC. Nighttime urinary frequency may serve as a complementary physical sign of MH in patients with UC.

Publisher

Wiley

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