A new liquid chromatography–quadrupole time of flight‐tandem mass spectrometry method development and validation for identification and ultra‐trace level quantification of genotoxic impurity 1,3‐diacetoxy‐2‐(acetoxymethoxy) propane in valganciclovir hydrochloride active pharmaceutical ingredient-Reference-Cited by-同舟云学术

A new liquid chromatography–quadrupole time of flight‐tandem mass spectrometry method development and validation for identification and ultra‐trace level quantification of genotoxic impurity 1,3‐diacetoxy‐2‐(acetoxymethoxy) propane in valganciclovir hydrochloride active pharmaceutical ingredient

Published:2022-01-19 Issue:3-4 Volume:5 Page:84-92
ISSN:2573-1815
Container-title:SEPARATION SCIENCE PLUS
language:en
Short-container-title:Separation Science Plus

Author:

Moorthy Manchuri Krishna¹^ORCID,Ali Shaik Mahammad¹,Reddy Gopireddy Venkata Subba²

Affiliation:

1. Department of Chemistry Jawaharlal Nehru Technological University Anantapur Ananthapuramu Andhra Pradesh India

2. Department of Chemistry Jawaharlal Nehru Technological University Anantapur, College of Engineering, Pulivendula Kadapa Andhra Pradesh India

Publisher

Wiley

Link

https://onlinelibrary.wiley.com/doi/pdf/10.1002/sscp.202100076

Reference29 articles.

1. https://go.drugbank.com/drugs/DB01610(last time accessed: October 30 2021).

2. https://clinicalinfo.hiv.gov/en/drugs/valganciclovir‐hydrochloride/patient(last time assessed: October 30 2021).

3. Valganciclovir

4. Novel synthesis of process related impurities of valganciclovir hydrochloride;Napoleon AA;Int J Pharm,2016

5. A Facile Synthesis of 9-(1,3-Dihydroxy-2-propoxymethyl)guanine (Ganciclovir) from Guanosine

Cited by 6 articles. 订阅此论文施引文献订阅此论文施引文献，注册后可以免费订阅5篇论文的施引文献，订阅后可以查看论文全部施引文献

1. Analytical Methodologies to Detect N-Nitrosamine Impurities in Active Pharmaceutical Ingredients, Drug Products and Other Matrices;Chemical Research in Toxicology;2024-08-19

2. Analytical Strategy for Low-Level Estimation of Unstable Genotoxic Boronate Ester Impurities;Organic Process Research & Development;2024-04-30

3. A novel LC-QTOF-MS/MS method for trace level identification and quantification of potential genotoxic impurity, 5-Nitro-2-(propylthio)pyrimidine-4,6-diol in ticagrelor drug substance;Analytical Chemistry Letters;2024-04-11

4. Combined green analytical principles and quality by design for ultraperformance liquid chromatography analytical method development, the characterization and in-silico toxicity prediction of Ixazomib degradation products using mass spectrometry;Green Analytical Chemistry;2024-03

5. Identification, characterisation and in silico ADMET prediction of ozenoxacin and its degradation products using high‐performance liquid chromatography‐photodiode array and liquid chromatography‐quadrupole time‐of‐flight‐tandem mass spectrometry;Rapid Communications in Mass Spectrometry;2023-12-07