Exploration of new and alternative sources of targeted bioflavonoids using ultra‐performance liquid chromatography‐tandem mass spectrometry

Author:

Singh Yatendra1,Rawat Priyanka12,Kumar Akhilesh12,Singh Sumit K.12,Mishra Dipak K.12,Kanojiya Sanjeev12

Affiliation:

1. Sophisticated Analytical Instrument Facility & Research, Division CSIR‐Central Drug Research Institute Lucknow India

2. Academy of Scientific and Innovative Research (AcSIR) Ghaziabad India

Abstract

AbstractBioflavonoids have exhibited remarkable pharmacological and biological properties. Moreover, many plants rich in flavonoids have been used as natural medicine or functional foods for thousands of years. Here, we introduce a liquid chromatography‐mass spectrometry‐based approach for the exploration of new/alternative sources of targeted bioflavonoids from plants of the Fabaceae family. The approach includes a selection of the plants from the Digital Library of Indian Medicine Plants and their Metabolites database, the literature survey of selected plant species, and a liquid chromatography‐mass spectrometry‐based experiment design for targeted analytes. Bioflavonoids were identified and structurally characterized based on tandem mass spectrometry fragmentation, comparing the retention time of authentic standard and multiple reaction monitoring transition for quantitative assessment. As a result of this study, 10 plant species were identified as a new sources of catechin, epicatechin, quercetin‐3 4'‐di‐O‐glucoside, isoorientin, orientin, vitexin, isovitexin, rutin, luteolin 7‐O‐glucoside, isoquercitrin, isorhamnetin‐3‐O‐rutinoside, quercetin, luteolin, and kaempferol. Moreover, 24 plant species were also recognized as alternative sources of targeted bioflavonoids. Moreover, the semi‐quantitative analysis of analytes revealed huge variations in the quantity of the analyzed flavonoids among the plants of the Fabaceae family. Consequently, the liquid chromatography‐mass spectrometry‐based approach was successfully utilized for the exploration of chemical diversity in the Fabaceae family and to identify new/alternative sources of targeted flavonoids.

Publisher

Wiley

Subject

Filtration and Separation,Analytical Chemistry

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