Amino‐Functionalized Metal Organic Framework‐Based Dispersive Micro‐Solid‐Phase Extraction Coupled With HPLC for Sensitive Quantification of Bisphenol A and Alkyl Phenols in Aqueous Samples

Abstract

ABSTRACTA sensitive analytical procedure for simultaneous extraction and determination of bisphenol A and alkyl phenols, namely, 4‐sec‐butylphenol, 4‐tert‐butylphenol, and 4‐tert‐amylphenol from aqueous samples with metal–organic framework (MOF)‐based dispersive micro‐solid‐phase extraction (D‐µSPE) and high‐performance liquid chromatography (HPLC) technique is developed. Sample contaminants were preconcentrated with amino‐functionalized aluminum MOF and later eluted with acetonitrile. The reconstituted sample was subjected to HPLC analysis. Various procedural parameters related to D‐µSPE were optimized. Under optimized preconcentration and chromatographic conditions, calibration curves with excellent linearity (R2 > 0.9986) in the working range of 0.25–100 ng mL−1 were prepared. Limit of detection (S/N = 3) for every analyte within the range of 0.020–0.022 ng mL−1 was obtained. Analyte's recovery 91.16%–97.01% (RSD = 1.02–3.01) for intraday and 89.86%–95.83% (RSD = 1.15–3.13) for inter‐day analysis was obtained from real water samples.