Affiliation:
1. Key Laboratory of Forest Plant Ecology Ministry of Education Northeast Forestry University Harbin People's Republic of China
2. College of Chemistry Chemical Engineering and Resource Utilization Northeast Forestry University Harbin People's Republic of China
3. Engineering Research Center of Forest Bio‐preparation Ministry of Education Northeast Forestry University Harbin People's Republic of China
4. Heilongjiang Provincial Key Laboratory of Ecological Utilization of Forestry‐based Active Substances Harbin People's Republic of China
Abstract
AbstractGreen extraction of the active lignans from Schisandra chinensis has received considerable attention due to their promising applications in the biomedical field. In this study, microwave‐assisted deep eutectic solvent method was used to simultaneously extract five lignans: Schizandrol A, Schizandrol B, Schisantherin A, Schisandrin A and Schizandrin B. The extraction parameters were optimized according to the calculated comprehensive score obtained from the analytic hierarchy process combined with the entropy weight method. The optimal extraction conditions were that the molar ratio of choline chloride and glycolic acid is 4:1, water content is 30% (V/V), solid–liquid ratio is 1:20 (Wg:VmL), extraction time is 20 min, and extraction temperature is 70°C, under which the extraction rate of the five lignans were 10.89, 8.616, 4.019, 4.893, and 5.318 mg/g. These results confirmed that our extraction method is efficient and feasible for green extraction of lignans from S. chinensis.
Funder
Fundamental Research Funds for the Central Universities