Affiliation:
1. School of Pharmacy Harbin Medical University Heilongjiang P. R. China
2. Beijing University of Chinese Medicine Beijing P. R. China
3. Institute of Clinical Pharmacy The Second Affiliated Hospital Harbin Medical University Harbin Heilongjiang P. R. China
4. Zhuhai People's Hospital Guangdong Provincial Key Laboratory of Tumor Interventional Diagnosis and Treatment Zhuhai Hospital Affiliated with Jinan University Jinan University Zhuhai Guangdong P. R. China
5. Guangzhou Traditional Chinese Medicine University Guangzhou P. R. China
Abstract
AbstractSalvia miltiorrhiza Bunge is a Traditional Chinese Medicine used for the treatment of diseases related to the heart and liver. Owing to the abundance of salvianolic acids and tanshinones, S. miltiorrhiza exhibits various pharmacological activities, such as stimulating blood circulation, eliminating blood stasis, relieving menorrhea and pain, and improving polydipsia. Neocryptotanshinone (NCTS) is one of the tanshinones isolated from S. miltiorrhiza and exhibits anti‐inflammatory, hypoglycemic, and preventive effects against cardiovascular diseases; however, its pharmacokinetic properties have not been reported to date. Therefore, a simple and reliable LC–MS/MS method was developed to determine absorption, distribution, and excretion of NCTS in rat physiological samples. We demonstrated that NCTS had high oral absolute bioavailability of 85.96% ± 25.32%, and it was rapidly distributed in both the heart and brain, and the fecal excretion of NCTS was the highest. This study provides a theoretical basis for further development of NCTS as a potential clinical candidate.
Subject
Filtration and Separation,Analytical Chemistry